Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-inflammatory Activity of Detoxified Bacterial Strains in Wistar Rats

  • Sur, Tapas Kumar (Department of Pharmacology, Institute of Post Graduate Medical Education & Research) ;
  • Auddy, Biswajit (Department of Pharmacology, Institute of Post Graduate Medical Education & Research) ;
  • Mitra, Susil Kumar (Department of Pharmacology, Institute of Post Graduate Medical Education & Research) ;
  • Sarkar, Dipak Kumar (Department of Pharmacology, Institute of Post Graduate Medical Education & Research) ;
  • Bhattacharyya, Dipankar (Department of Pharmacology, Institute of Post Graduate Medical Education & Research)
  • Received : 2010.03.16
  • Accepted : 2010.08.27
  • Published : 2010.09.30
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Abstract

A mixture of several detoxified bacterial strains ($Sterodin^{(R)}$) has been studied for anti-inflammatory effect in Wistar rats on carrageenin, dextran and prostaglandin $E_1$ ($PGE_1$) induced edema in acute model and cotton pellet and carrageenin induced sub-acute model, while, Freund's adjuvant induced chronic model. The bacterial strains showed strong inhibitory activity in acute, sub-acute and chronic models of inflammation. Further, it reduced ${\alpha}1$ acid glycoprotein and ${\alpha}2$ macroglobulin levels in serum and prostaglandin $E_2$ in inflamed paw. These results indicated that the bacterial strains probably act through prostaglandin mediatory pathways and may be useful in treatment of inflammation.

Keywords

References

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