Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Dosage and Duration Effects of Korean Red Ginseng Intake on Frequency of Gross Deletions in the nef Gene

  • Cho, Young-Keol (Department of Microbiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jung, You-Sun (Department of Microbiology, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2010.05.26
  • Accepted : 2010.07.23
  • Published : 2010.09.30
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Abstract

In the present study, we investigated whether a gross deletion in the nef gene ($g{\Delta}nef$) is induced by Korean red ginseng (KRG) intake. Ten patients were treated with KRG powder for 3 years in the absence of antiretroviral drug therapy. On average, $3,555{\pm}1,042\;g$ KRG was administered per person over $36.1{\pm}2.4$ months. There was a mild decrease in CD4 T cell count ($75{\pm}110/{\mu}L$) over the $36.1{\pm}2.4$ months (p = 0.059). We obtained 355 nef amplicons using 71 peripheral blood mononuclear cell samples over a 3-year period. All ten patients exhibited g${\Delta}$nef (range, 3.2 to 45.9%). At baseline, 3 of 78 amplicons (3.8%) exhibited $g{\Delta}nef$, whereas 18.8% (52/277) revealed $g{\Delta}nef$ during KRG-intake (p<0.001). The proportion of $g{\Delta}nef$ was significantly correlated with monthly dose of KRG (r=0.89, p<0.001). The median time for first detection of $g{\Delta}nef$ was 13 months. In conclusion, our data show that $g{\Delta}nef$ is inducible by KRG intake and its proportion is dependent on the duration of KRG intake and dose of KRG.

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References

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