녹용약침과 웅담.우황(BU)약침이 정상인의 심박변이도(HRV)에 미치는 영향

The Effects of Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus.Fel Ursi Pharmacopuncture on the Heart Rate Variability

  • 이휘용 (우석대학교 부속한방볍원 침구과) ;
  • 이진복 (우석대학교 부속한방볍원 침구과) ;
  • 조이현 (우석대학교 부속한방볍원 침구과) ;
  • 송범용 (우석대학교 부속한방볍원 침구과) ;
  • 육태한 (우석대학교 부속한방볍원 침구과)
  • Lee, Hwi-Yong (Department of Acupuncture & Moxibustion, Woosuk University Hospital of Oriental Medicine) ;
  • Lee, Jin-Bok (Department of Acupuncture & Moxibustion, Woosuk University Hospital of Oriental Medicine) ;
  • Cho, Yi-Hyun (Department of Acupuncture & Moxibustion, Woosuk University Hospital of Oriental Medicine) ;
  • Song, Beom-Yong (Department of Acupuncture & Moxibustion, Woosuk University Hospital of Oriental Medicine) ;
  • Yook, Tae-Han (Department of Acupuncture & Moxibustion, Woosuk University Hospital of Oriental Medicine)
  • 투고 : 2009.11.25
  • 심사 : 2009.12.15
  • 발행 : 2010.02.20

초록

Objectives : This study was to investigate the effects of Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi Pharmacopuncture on autonomic nervous system with Heart Rate Variability(HRV). Purpose of the trial was to observe what influence Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi pharmacopuncture have on the autonomic nervous system. Methods : 40 healthy male volunteers were divided into two experimental groups, such as Cervi Pantotrichum Cornu Pharmacopuncture group and Bovis calculus Fel Ursi Pharmacopuncture group. Study design was a randomized, double-blind clinical trial. 20 subjects in one experimental group were injected Cervi Pantotrichum Cornu Pharmacopuncture, 20 subjects in other experimental group were injected hydrolyzed Bovis calculus Fel Ursi Pharmacopuncture at GB21(Kyonjong). We measured HRV 7 times : baseline measurement and every 5 minutes for 30 minutes after injection. The SPSS 15.0 for Windows was used to analyze the data by the paired t-test(in group) and independent sample t-test(between the groups). Results A. Time Domain Analysis 1. Analysis of Mean HRV, SDNN and Complexity After injection of Cervi Pantotrichum Cornu Pharmacopuncture, Mean HRV was significantly decreased all the times after injection. SDNN was significantly increased at immediate and 25 minute after injection. Complexity was significantly decreased only at 15 minute after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, Mean HRV was significantly decreased all the times after injection. Complexity was significantly decreased at 15 minutes after injection. 2. Analysis of HRV index, pNN50 After injection of Cervi Pantotrichum Cornu Pharmacopuncture, HRV index was significantly increased immediately after injection. pNN50 was significantly decreased at immediately, 20 and 25 minutes after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, HRV index was significantly increased immediately after injection. pNN50 was significantly decreased at immediate and 25 minutes after injection. B. Frequency Domain Analysis 1. Analysis of Ln(TP), Ln(HF), Ln(LF), Ln(VLF) After injection of Cervi Pantotrichum Cornu Pharmacopuncture, Ln(TP) was significantly increased at immediate and 25 after injection. Ln(HF) was significantly increased all the times after injection. Ln(LF) was significantly increased at 15, 20 and 25 minutes after injection. Ln(VLF) was significantly increased at immediate and 25 minutes after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, Ln(TP) was significantly increased at immediately and 25 after injection. Ln(LF) was significantly increased at 20 and 25 minutes after injection. Ln(VLF) was significantly increased at immediate and 25 minutes after injection. Conclusions : We results suggest that Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi Pharmacopuncture in healthy adult men tend to activate the autonomic nervous system and sympathetic nervous system within normal range.

키워드

참고문헌

  1. 대한침구학회 교재편찬위원회 편저. 침구학(上, 中, 下). 파주 : 집문당. 2008 : 235-6(上), 408-14(中).
  2. 대한약침학회 학술위원회. 약침학. 서울 : 엘스비어코리아(유). 2008 : 9-12.
  3. Kamath MV, Fallen EL. Power spectral analysis of heart rate variability : a noninvasive signature of cardiac autonomic function. Crit Rev Biomed Eng. 1993 ; 21(3) : 245-311.
  4. 전국한의과대학 본초학교실. 본초학. 서울 : 영림사. 1991 : 207, 224, 545.
  5. 설현, 육태한. 견정혈 황련해독탕약침이 심박변이율(HRV)에 미치는 영향. 대한침구학회지. 2004 ; 21(6) : 37-50.
  6. 노정두, 김락형, 송범용, 육태한. 산삼약침이 정상인의 심박변이율(HRV)에 미치는 영향. 대한약침학회지. 2008 ; 11(1) : 55-69.
  7. 신진철, 김락형, 송범용, 육태한. 생지황약침이 정상인의 심박변이율(HRV)에 미치는 영향. 대한약침학회지. 2008 ; 11(1) : 83-97.
  8. Shin KS, Minamitani H, Onishi, Yamazaki H, Lee M. Autonomic differences between ath-letes and nonathletes ; spectral analysis approach. Med Sci Sports Exerc. 1997 ; 29(11) : 1482-90. https://doi.org/10.1097/00005768-199711000-00015
  9. Akselrod S, Gordon D, Uble FA, Shannon DC, Barger AC, Cohen RJ. Power spectral analysis of heart rate fluctuation : a quantitative probe of beat-to-beat cardiovascular control. Science. 1981 ; 213, 221, 222.
  10. Pomeranz B, Macaulay R, Caudill M, Kuts I, Adam D, Gordon D et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol. 1985 ; 248 : 151-3.
  11. Kamath MV, Fallen EL. Power spectral analysis of heart rate variability : anoninvasive signature of cardiac autonomic function. Crit Rev Biomed Eng. 1993 ; 21(3) : 245-311.
  12. Task force of The European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate Variability standards of measurement, physiological interpretation, and clinical use. Circulation. 1996 ; 93 : 1043-65. https://doi.org/10.1161/01.CIR.93.5.1043
  13. Pagani M, Fuflann R, Dell'Orto S, Pizzinelli P, Baselli G, Cerutti S, Federico L, Malliani A, Simultaneous Analysis of Beat by Beat Systemic Arterial Pressure and Heat Rate Variabilities in Ambulatory Patients. J Hypertention. 1985 ; 3 : 83-5.
  14. 하선윤, 김동민, 조성연, 임인환, 김용석, 남상수. 만성통증환자의 심박변이도(HRV)분석을 통한 자율신경계 특징에 관한 연구. 대한침구학회지. 2008 ; 25(6) : 35-46.
  15. 정인태, 이상훈, 김수영, 차남현, 김건식, 이두익, 이재동, 임사비나, 이윤호, 최도영. 만성두통환자에 대한 침치료가 심박변이도(HRV)에 미치는 영향. 대한침구학회지. 2005 ; 22(3) : 105-12.
  16. 이상훈, 김은정, 박연철, 고영진, 남동우. 침자극이 뇌졸중 환자의 심박변이도에 미치는 영향. 대한침구학회지. 2006 ; 23(1) : 135-43.
  17. 조이현, 유정석, 이휘용, 송범용. 7구역진단기의 Factor AA 제1, 2, 3구역 유형과 임상지표와의 상관성 연구. 대한침구학회지. 2008 ; 25(6) : 67-76.
  18. 김정신, 황욱, 배기태, 남상수, 김용석. 소부혈 자침이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향. 대한침구학회지. 2004 ; 21(5) : 227-39.