Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-allergic effects of Perilla frutescens var. acuta Kudo 30% ethanol extract powder

  • Oh, Hyun-A (Cancer Preventive Material Development Research Center, Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Sung-Hoon (Cancer Preventive Material Development Research Center, Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Cha, Wung-Seok (Department of Korean Medical History, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Hyung-Min (Department of Pharmacology, Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Hyun-Ja (Biochip Research Center, Hoseo University)
  • Received : 2009.12.30
  • Accepted : 2010.08.24
  • Published : 2010.09.30
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Abstract

Perilla frutescens var. acuta Kudo (PF) is a traditional Korean medicinal herb for allergic reaction regulation. In the present study, we investigated the effect of 30% ethanol extract powder of PF (EPPF) and rosmarinic acid (RA), the active compound of EPPF on various allergic reactions using in vivo and in vitro models. EPPF and RA significantly inhibited compound 48/48-induced systemic anaphylactic reaction and histamine release (P < 0.05). In addition, EPPF and RA significantly inhibited passive cutaneous anaphylaxis (PCA) in a dose-dependent manner (P < 0.05). These effects were stronger than those of disodium cromoglycate, the reference drug tested. EPPF and RA also significantly inhibited production of inflammatory cytokines, tumor necrosis factor-a interleukin (IL)-6, and vascular endothelial growth factor on the PCA reaction and phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cell line, HMC-1 cells (P < 0.05). Moreover, EPPF and RA showed an inhibitory effect on lipopolysaccharide (LPS)-induced IL-4 production from whole spleen cells. Finally, EPPF and RA significantly decreased IL-4-dependent IgE production by LPS-stimulated whole spleen cells (P < 0.05). In conclusion, these results indicate that EPPF has potent anti-allergic activities.

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References

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