Advances in Traditional Medicine

  • 제10권3호
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  • Pages.214-221
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  • 2010
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Clematis chinensis suppresses lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 in mouse BV2 microglial cells

  • Chun, Hae-Jin (Department of Physiology, College of Oriental Medicine, Kyung Won University) ;
  • Lee, Choong-Yeol (Department of Physiology, College of Oriental Medicine, Kyung Won University) ;
  • Lee, Jin-Woo (Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Sung, Yun-Hee (Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Sung-Eun (Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Young-Sick (Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Shin, Mal-Soon (Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Chang-Ju (Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Lee, Hye-Jung (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Kim, Dong-Hee (Department of Ophthalmology, College of Medicine, Chungju Hospital, Konkuk University)
  • 투고 : 2010.08.24
  • 심사 : 2010.09.07
  • 발행 : 2010.09.30
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초록

Clematis chinensis is the root of Clematis chinensis OSBECK and is classified in Ranunculaceae. Clematis chinensis is a traditional medicinal herb possesses analgesic, diuretic, anti-tumorigenic, and anti-inflammatory effects. In this study, the effect of aqueous extract of Clematis chinensis against lipopolysaccharide-induced inflammation was investigated in mouse BV2 microglial cells. The aqueous extract of Clematis chinensis at the respective concentration was treated one hour before the lipopolysaccharide treatment in mouse BV2 microglial cells. From the present results, pre-treatment with the aqueous extract of Clematis chinensis suppressed prostaglandin E2 synthesis and nitric oxide production by inhibiting on the lipopolysaccharide-stimulated cyclooxygenase-2 and inducible nitric oxide synthase expressions in mouse BV2 microglial cells. The present study suggests that Clematis chinensis may offer a valuable mean of therapy for brain inflammatory diseases.

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참고문헌

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