A Probabilistic Assessment of Human Health Risk from Arsenic-Contaminated Rice Grown Near The Mining Areas of Korea

  • Paik, Min-Kyoung (Department of Crop Life Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Won-Il (Department of Crop Life Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Yoo, Ji-Hyock (Department of Crop Life Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Jin-Kyoung (Department of Crop Life Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Im, Geon-Jae (Department of Crop Life Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Hong, Moo-Ki (Department of Crop Life Safety, National Academy of Agricultural Science, Rural Development Administration)
  • Received : 2010.01.08
  • Accepted : 2010.04.02
  • Published : 2010.06.30


Chronic exposure to Arsenic (As) causes significant human health effects including various cancers. Total As concentrations from 300 polished rice samples cultivated near the mining areas in Korea were analyzed to estimate a probabilistic assessment of human health risk from As-contaminated rice. The mean of total As concentrations in rice was 0.09 mg/kg and lognormal distribution model was set for total As concentrations. Human health risk for As in rice was estimated using gender-specific rice consumption data and average daily dose (ADD). While cancer risk (CR) and hazard quotient (HQ) were calculated using oral cancer slope factor (OCSF) and Reference dose (RfD) suggested by the U.S. EPA. Mean of CR posed by total As was 2.16 (for male) and 1.83 (for female) per 10,000. The HQ for general population from rice cultivated near the mining areas in Korea was below 1 as the $50^{th}$ percentile of general population. However, less than 10% of general population consuming rice cultivated near the mining areas would exceed 1.0. This result is similar with those from each gender-specific group.

만성으로 비소에 노출될 경우 암을 비롯하여 인체에 심각한 악영향이 나타날 수 있다. 본 연구에서는 우리나라의 광신인근에서 재배된 벼의 백미시료 300점에 함유된 총 비소를 분석하고, 이 백미 시료만을 섭취했을 경우의 인체위험도를 확률적 접근법을 이용하여 평가하였다. 300점의 백미에 함유된 총 비소의 함량은 0.09 mg/kg으로 lognormal 분포형태를 나타내었다. 우리나라 전체인구와 성별로 나눠 이 백미시료만을 섭취했을 경우 1일 총비소 노출량을 평가하였으며, EPA의 발암력과 기준참고치를 그거로 발암위해와 비발암위해를 정량화하였다. 광산인근 백미 섭취를 통한 발암위해의 평균은 만명기준 남성 2.16명, 여성 1.83에서 1.0 이하로 나타났다. 광산인근 백미만을 섭취하는 경우 전체 인근의 10% 미만이 비발암위해를 보이는 것으로 나타났다. 그러나, 이는 우리나라 광산인근에서 재배된 300점 백미시료에 대한 자료를 근거로 도출된 결과로서 우리나라 모든 광신인근 지역의 백미를 대표할 수 없는 한계가 존재한다.



  1. Abedin, M.J., Cotter-Howells, J. and Meharg, A.A.: Arsenic uptake and accumulation in rice (Oryza sativa) irrigated with contaminated water. Plant and Soil, 240, 311-219 (2002). https://doi.org/10.1023/A:1015792723288
  2. Guha, M.D.N., Haque, R., Ghosh, N., De, B.K., Santra, A., and Chokraboro, E.: Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal, India. Int. J. Epidemiol, 27, 871-877 (1998). https://doi.org/10.1093/ije/27.5.871
  3. Guo, H.R., Chiang, H.S., Hu, H., Lipsitz, S.R. and Monsor R.R.: Arsenic in drinking watger and incidence or urinary cancers. Epidemiology, 8, 545-550 (1997). https://doi.org/10.1097/00001648-199709000-00012
  4. Lien, H.C., Tsai, T.F., Lee, Y.Y. and Hsiao, C.H.: Merkel cell carcinoma and chronic arsenicism. J. Am. Acad. Dermatol, 42, 641-643 (2001).
  5. Mandal B.K. and Suzuki K.T. : Arsenic round the world: a review. Lalanta, 58, 201-205 (2002).
  6. Yu, H.S., McCrath, S.P. and Zhao, F.J. : Rice is more efficient in arsenite uptake and translocation than wheat and barley. Plant and Soil. In press. (2009).
  7. International Agency for Research on Cancer: Some Drinking-water Disinfectants and Contaminants, Including Arsenic; IARC Monograps on the Evaluation of Carcinogenic Risks to Humans; World Health Organization: Geneva, vol. 84 (2004).
  8. National Research Council. Arsenic in Drinking Water-2001 Update; National Academy Press: Washington, D.C. USA (2001).
  9. Williams, P.N., Price, A.H., Raab, A., Hossanin, S.A., Feldmann, J. and Jeharg, A.A.: Variation in arsenic speciation and concentration in paddy rice related to dietary exposure. Environ. Sci Technol, 29, 5531-40 (2005).
  10. Tsuji, J.S., Yost, L.J., Barraj, L.M., Scrafford, C.G. and Mink, P.J.: Use of background inorganic arsenic exposure to provide perspective on risk assessment results. Reg. Toxicol. Pharmacol, 48, 59-63 (2007). https://doi.org/10.1016/j.yrtph.2007.01.004
  11. KNHANES: In-depth Analysis on the 3rd (2005) Korea Health and Nutrition Examination Survey -Nutrition survey- (2007).
  12. Meharg, A.A, Sun, G., Willams, P.N., Adamako, E., Deacon, C., Zhu, Y.G. Feldmann, J. and Raab, A.; Inorganic arsenic levels in baby rice are of concern. Environ. Pollut, 152, 746-749 (2008). https://doi.org/10.1016/j.envpol.2008.01.043
  13. Korea Food and Drug Administration (KFDA): Chinese food standard II (2007).
  14. Korea Food and Drug Administration (KFDA): Chinese food standard III (2007).
  15. Food Standards Australia New Zealand (FSANZ): Australian New Zealand Food Standards Code, Standard 1.4.1 contaminants and natural toxicants (2009).
  16. Japan Ministry of Health, Labour and Welfare: Specifications and standards for food, food additives, etc. (2006).
  17. Yu, D.H.: A probabilistic assessment of skin cancer risk from inorganic arsenic. Entern. J. Environ. Studies, 57, 93-108 (1999). https://doi.org/10.1080/00207239908711258
  18. Juhasz, A.L., Smith, E., Weber, J., Rees, M., Rofe, A., Kuchel, T., Sansom, L. and Naidu, R.: In vivo assessment of arsenic bioavilability in rice and its significance for human health risk assessment. Environ. Health Persepct, 114, 1826-1831 (2006).
  19. U.S. EPA: Arsenic, Inorganic, Integrated Risk Information System. Office of Research and development, Washington DC, USA. (1993).
  20. Korea Food an drug Administration (KFDA): Survey on the Heavy metals in Agricultural Products (2006).
  21. Alam, M.G.M., allinson, G., Stagnitti, F., Tanaka, A. and Westbrooke, M.: Metal concentrations in rice and pulses of Samta Billage, Bangladesh. Bull. Environ. Contam. Toxico.l 69, 323-329 (2002). https://doi.org/10.1007/s00128-002-0065-y
  22. Meharg, A.A. and Rahman, M.D.: Arsenic contamination of Bangladesh paddy field soils: implications for rice contribution to arsenic consumption. Environ. Sci. Techno, 37, 229-234 (2004).
  23. Schoof, R.A., Yost, L.J., Eickhoff, J., Crecelius, E.A., Cragin, D.W., Meacher, D.M.: A market basket wurvey or inorganic arsenic in food. Food Chem. Toxicol, 27, 839-846 (1999).
  24. Klassen, C.D. and Eaton, D.L.: Principles of toxicology. In: Amdur MO, Doull J, and Klaassen CD, (eds), Casarett and Doull's Toxicology: The Basic Science of Poison, Pergamon Press, NY, USA. pp. 12-49 (1991).
  25. Smith, E., Juhasz, A.L., Weber, J. and Naidu, R.: Arsenic uptake and speciation in rice plants grown under greenhouse conditions wit arsenic contaminated irrigation water. Sci. of the Total Environm, 392, 277-283 (2008). https://doi.org/10.1016/j.scitotenv.2007.11.023
  26. World Health Organization (WHO): Guidelines for Drinking water quality. 2nd ed. Geneva (1993).
  27. U.S. EPA: Exposure factors handbook (EPA/600/8-89/043), Environmental Protection Agency, Office of Research and Development, OH, USA (1989).
  28. Wang, S.L., Chiou, J.M., Chen, C.J., Tseng, C.H., Chou W.L. and Wang C.C.: Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan. Environmen. Health Perspect, 3(2), 155-159 (2003).
  29. Joint FAO/WHO food standard porgramme codex committee on contaminants in food: document for information and use in discussion related to contaminants and toxins in the GSCTF, Rotterdam, The Netherlands (2009).