Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Role of MRI in Diagnostic Evaluation of Papillary Lesions of the Breast

유방의 유두상 병변의 진단에서 자기공명영상의 역할

  • Lee, So-Mi (Department of Radiology, Kyungpook National University Hospital) ;
  • Kim, Hye-Jung (Department of Radiology, Kyungpook National University Hospital) ;
  • Gwak, Yeon-Joo (Department of Radiology, Kyungpook National University Hospital) ;
  • Lee, Hui-Joong (Department of Radiology, Kyungpook National University Hospital) ;
  • Jang, Yun-Jin (Department of Radiology, Kyungpook National University Hospital) ;
  • Shin, Kyung-Min (Department of Radiology, Kyungpook National University Hospital) ;
  • Park, Ji-Young (Department of Pathology, Kyungpook National University Hospital) ;
  • Jung, Jin-Hyang (Department of Surgery, Kyungpook National University Hospital)
  • 이소미 (경북대학교병원 영상의학과) ;
  • 김혜정 (경북대학교병원 영상의학과) ;
  • 곽연주 (경북대학교병원 영상의학과) ;
  • 이희중 (경북대학교병원 영상의학과) ;
  • 장윤진 (경북대학교병원 영상의학과) ;
  • 신경민 (경북대학교병원 영상의학과) ;
  • 박지영 (경북대학교병원 병리과) ;
  • 정진향 (경북대학교병원 외과)
  • Received : 2009.10.23
  • Accepted : 2010.05.13
  • Published : 2010.06.30
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Abstract

Purpose : To evaluate the role of magnetic resonance imaging (MRI) in the diagnosis of papillary lesions of the breast. Materials and methods : Among 45 papillary lesions diagnosed at ultrasonography-guided core biopsy (USCB), 27 benign papillary lesions in 22 patients who underwent breast MRI were reviewed. The excsional biopsy was performed in 1-10 days after MRI was done. In MRI findings, lesions were considered suspicious if they show irregular, rim enhancement, or linear enhancement in morphologic evaluation, or washout enhancement pattern of delayed phase in dynamic enhancement characteristics. Diffusionweighted images were analyzed according to visibility of lesions. MRI findings were correlated with pathologic results at excisional biopsy. Results : At excisional biopsy, two lesions (9%) were diagnosed malignant in 22 benign papillary lesions without atypia by USCB and 4 (80%) were malignant in 5 benign papillary lesions with atypia by USCB. Among 18 lesions detected on MRI, 16 lesions showed suspicious findings on MRI, 11 lesions (69%) were diagnosed as benign and 5 (31%) were malignant. Among 12 lesions detected on diffusion weighted imaging, 10 lesions were diagnosed as benign and 2 were malignant. MRI findings were not significantly correlated with pathologic results at excisional biopsy. Conclusion : MRI findings were not useful to predict malignancy in benign papillary lesions diagnosed at USCB, because MRI findings of these were mostly suspicious (88.9%, 16/18). The benign papillary lesion should be included in the false positive lesion on breast MRI.

목적 : 유방의 유두상 병변의 진단에 있어 자기공명영상의 역할에 대해 알아보고자 한다. 대상 및 방법 : 초음파 유도하 핵생검에서 양성 유두상 병변으로 진단된 45예 중 자기공명영상을 시행한 22명의 환자 27예를 대상으로 하였다. 자기공명영상 시행 1-10일 후 절제 생검을 시행하였다. 자기공명영상 소견은 형태학적 기준에서 불규칙하거나 환형 또는 선형 조영증강을 보이거나 조영증강 양상에서 지연기 조영유실을 보이는 경우를 의심스러운 병변으로 분류하였다. 확산강조영상에서 병변의 발견 여부도 알아보았다. 자기공명영상 소견이 절제 생검 결과와 관련이 있는지 알아보았다. 결과 : 핵생검에서 비정형성이 없는 22예의 양성 유두상 병변 중 2예(9%), 비정형성이 있는 5예의 양성 유두상 병변 중 4예(80%)가 절제 생검에서 악성으로 진단되었다. 자기공명영상에서 발견된 18예 중 16예에서 암이 의심되는 소견을 보였으며, 절제 생검에서 양성이 11예(69%), 악성이 5예(31%)였다. 확산강조영상에서 보이는 12예 중 10예가 양성, 2예가 악성으로 진단되었다. 자기공명영상 소견은 절제 생검 결과와 상관이 없었다. 결론 : 핵생검에서 진단된 양성 유두상 병변의 자기공명영상 소견은 대부분(88.9%, 16/18)에서 암이 의심되는 소견을 보여 악성 예측에 도움이 되지 않았으며 자기공명영상에서 위양성 소견을 보이는 병변에 양성 유두상 병변이 포함되어야 할 것이다.

Keywords

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