Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Antioxidant Effects of Hovenia Dulcis in the Streptozotocin-Induced Diabetic Rats

당뇨병 유발 흰쥐에서 헛개나무 추출물의 항산화 효과

  • Ahn, Byung-Soo (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Joo-Wan (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Hong-Tae (Busan Metropolitan City Institute of Health and Environment) ;
  • Lee, Sung-Dong (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Keun-Woo (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
  • 안병수 (경북대학교 수의과대학) ;
  • 김주완 (경북대학교 수의과대학) ;
  • 김홍태 (부산광역시 보건환경연구원) ;
  • 이성동 (경북대학교 수의과대학) ;
  • 이근우 (경북대학교 수의과대학)
  • Accepted : 2010.08.13
  • Published : 2010.08.30
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Abstract

Diabetes mellitus (DM) is one of the highest morbidity and mortality diseases and is a state of increased oxidative stress. This study was carried out to evaluate anti-oxidant activities of Hovenia dulcis Thunberg in streptozotocin (STZ)-induced diabetic rats. Eighty Sprague-Dawley rats, 6 week-old, were divided into 3 groups at 12hours after STZ induction; Diabetic control group (DW per os DC group), Glibencliamide group (5 mg/kg glibenclimide per os, GLI group) and Hovenia dulcis group (100 mg/kg Hovenia dulcis Thunberg water extract per os HDT group). Normal control group (NC group) was just injected with DW instead of STZ. On day 5, superoxide dismutase (SOD) and catalase activities of HDT group were significantly (P < 0.05) increased compared with DC group and glutathione peroxidase activities of HDT group was more increased than DC group but there was no significant difference.

Keywords

References

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