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Textual Research : Indication and Dosage of Panax Ginseng during Lactation

모유수유 중 인삼의 적응증과 용량에 관한 기존한약서 고찰

  • Received : 2010.10.29
  • Accepted : 2010.11.09
  • Published : 2010.11.30

Abstract

Purpose: To provide basic informations for guidelines of Ginseng usage during lactation. Method: Based on a regulation of scope and preparation of herbal prescriptions by Ministry of health and welfare of Korea, we selected the formulae for postpartum care and disease in 7 Korean Medical Classics. And we searched the number of formulae including Ginseng, dosage and indications of Ginseng in formulae in those books. Results: The range of Ginseng dosage during lactation from medical classics is 1.5-18.75g/day for medical purposes. Indications of Ginseng are lethargy, excessive bleeding, asthma, fever, cold, pain, dizziness, mental disorder, spasm, digestive problem, constipation, diarrhea, urinary incontinence, edema, breast engorgement, lack of breastmilk, breast ulcer, etc. But Ginseng had not been used in the case of stroke, epistaxis, beginning of mastitis, tumor of lower abdomen. Conclusions: Ginseng should be recommended less than 1.5g/d as a nutritional supplement. If breastfeeding woman wants to take Ginseng as a medication or as a tonic, she should consult with a official specialist about proper prescription and dosage instead of risky random medication.

Keywords

References

  1. Walker M et al. Core Curriculum for Lactation Consultant Practice(2nd edition). Jones&Bartlett. 2006:333-64.
  2. 전병선. 고려인삼의 유통 현황과 명품화 제품 개발 전략. Food Preservation and Processing Industry. 2009;8(2) :47-51.
  3. Hale T. Medications and Mother's Milk(14th edition). Amarillo:Pharmasoft Publishing. 2010:13-20.
  4. Seely D et al. Safety and Efficacy of Panax Ginseng during Pregnancy and Lactation. Can J Clin Parmacol. 2008 ;15(1):e87-e94.
  5. Wiklund IK et al. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Int J Clin Pharmacol Res. 1999;19 :89-99.
  6. Greenspan EM. Ginseng and vaginal bleeding[letter]. JAMA. 1983;249:2018. https://doi.org/10.1001/jama.249.15.2018
  7. Punnonen R, Lukola A. Oestrogenlike effect of ginseng. Br Med J. 1980;281:1110. https://doi.org/10.1136/bmj.281.6248.1110
  8. Cheng TO. Ginseng-Warfarin interaction. ACC Current Journal Review. 2000 ;9(1):84. https://doi.org/10.1016/S1062-1458(99)00042-2
  9. Siegel RK. Ginseng abuse syndrome: problems with panacea. JAMA 1979; 241(15):1614-5. https://doi.org/10.1001/jama.241.15.1614
  10. 식품의약품안전청. 건강기능식품에 사용할 수 없는 원료 등에 관한 규정 일부개정고시 42. 2008.
  11. 보건복지부. 기존한약서(보건사회부 예규 제233호, 1969)에 대한 잠정규정 개정. 2008.
  12. 兪孝通, 盧重禮, 朴允德. 새천년 鄕藥集成方. 서울:정담출판사. 2000:3-953.
  13. 李梃. 醫學入門. 서울:고려의학. 1998 :48-605.
  14. 許浚. 原本東醫寶鑑. 서울:남산당. 1996:72-671.
  15. 張景岳. 景岳全書. 서울:대성문화사. 1997:(上)4-765, (下)1-887.
  16. 龔廷賢. 壽世保元. 北京:人民衛生出版社. 1993:3-779.
  17. 康命吉. 濟衆新編. 서울:韓國醫學大系 18. 1992:93-630.
  18. 黃道淵. 對譯證脈․方藥合編. 서울: 남산당. 2000:51-371.
  19. 한국한의학연구원. 한의학 지식정보자원 웹서비스(jisik.kiom.re.kr).
  20. 제중신편 원문 데이터베이스. 누리미디어. 2003.
  21. 방약합편 원문 데이터베이스. IBOOKPIA. 2002.
  22. 이선영 등. 수유부의 유선질환을 의미하는 한의학 용어 연구. 한의학연구원논문집. 2010;16(2):1-7.
  23. 미국 약전 천연물 DB. http://naturaldatabase.therapeuticresearch.com.
  24. Klein S, Rister R, Riggins C. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. The Americal Botanical Council. 1998.
  25. 남기열, 박종대. 인삼의 한의학적 및 현대임상적 측면에서의 복용량 검토. J Ginseng Res. 2000;24(2):99-105.
  26. 남기열. 고려인삼의 주요 효능과 그 임상적 응용. J Ginseng Res. 2002; 26(3):111-31. https://doi.org/10.5142/JGR.2002.26.3.111
  27. Kim SN et al. Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. Journal of Pharmaceutical and Biomedical Analysis. 2007;45(1) :164-70. https://doi.org/10.1016/j.jpba.2007.05.001
  28. 식품의약품 안전청. 건강기능식품의 기준 및 규격 일부개정고시 7호. 2010.
  29. Hwang YP, Jeong HG. Ginsenoside Rb1 protects against 6-hydroxydopamin -induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt /Nrf2-dependent pathway in human dopaminergic cells. Toxicol Appl Pharmacol. 2010;242(1):18-28. https://doi.org/10.1016/j.taap.2009.09.009
  30. Lau WS et al. Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway. J Steroid Biochem Mol Biol. 2008;108(1-2):64-71. https://doi.org/10.1016/j.jsbmb.2007.06.005
  31. Lau WS et al. Mitogen-activated protein kinase(MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer(MCF-7) cells. Br J Pharmacol. 2009;156(7):1136-46. https://doi.org/10.1111/j.1476-5381.2009.00123.x
  32. Leung KW et al. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br J Pharmacol. 2007;152(2):207-15. https://doi.org/10.1038/sj.bjp.0707359
  33. Papapetropoulos A. A ginseng-derived oestrogen receptor beta (ERbeta) agonist, Rb1 ginsenoside, attenuates capillary morphogenesis. Br J Pharmacol. 2007;152(2):172-4. https://doi.org/10.1038/sj.bjp.0707360
  34. 백덕우, 이서윤, 지형준. 인삼 Saponin이 Prolactin 분비에 미치는 효과. 생약학회지. 1978;9(1):33-9.