Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Comparison of Concentration of Urinary Metabolites of PAHs from Smokers and Nonsmokers

흡연자와 비흡연자의 소변 중 다환방향족탄화수소(PAHs) 대사체 농도 비교

  • Kho, Young-Lim (Department of Health, Environment & Safety, Eulji University) ;
  • Lee, Eun-Hee (Graduate School of Health Science, Far East University)
  • 고영림 (을지대학교 보건환경안전학과) ;
  • 이은희 (극동대학교 보건과학대학원)
  • Received : 2011.08.31
  • Accepted : 2011.12.26
  • Published : 2011.12.31
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Abstract

This study investigated urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) in the urine of smokers and non-smokers by liquid chromatography triple quordrupole tandem mass spectroscopy (LC/MS/MS). Compounds analyzed for urinary biomarkers of PAHs were five mono-hydroxylated PAHs metabolites; 1-naphthol, 2-naphthol, 1-hydroxypyrene(1-OHP), 3-phenanthrol, 2-fluorenol. Urine samples were pretreated by enzymatic hydrolysis and solid phase extraction method. Smokers were composed of 17 men and five women; non-smokers 17 men and 16 women. Smoking increased urinary concentrations of five PAHs metabolites significantly higher than those of nonsmokers. Statistically significant correlations among the five PAHs metabolites were shown. The results suggest that LC/MS/MS technology should be useful in the environmental health discipline.

Keywords

References

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