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Improvement of Cognitive Deficit in Alzheimer's Disease Patients by Long Term Treatment with Korean Red Ginseng

  • Heo, Jae-Hyeok (Department of Neurology, Seoul Medical Center) ;
  • Lee, Soon-Tae (Department of Neurology, Seoul National University Hospital) ;
  • Oh, Min-Jung (Department of Neurology, Seoul National University Hospital) ;
  • Park, Hyun-Jung (Department of Neurology, Seoul National University Hospital) ;
  • Shim, Ji-Young (Department of Neurology, Seoul National University Hospital) ;
  • Chu, Kon (Department of Neurology, Seoul National University Hospital) ;
  • Kim, Man-Ho (Department of Neurology, Seoul National University Hospital)
  • Received : 2011.07.05
  • Accepted : 2011.10.13
  • Published : 2011.12.26

Abstract

A 24-week randomized open-label study with Korean red ginseng (KRG) showed cognitive benefits in patients with Alzheimer's disease. To further determine long-term effect of KRG, the subjects were recruited to be followed up to 2 yr. Cognitive function was evaluated every 12 wk using the Alzheimer's Disease Assessment Scale (ADAS) and the Korean version of the Mini Mental Status Examination (K-MMSE) with the maintaining dose of 4.5 g or 9.0 g KRG per d. At 24 wk, there had been a significant improvement in KRG-treated groups. In the long-term evaluation of the efficacy of KRG after 24 wk, the improved MMSE score remained without significant decline at the 48th and 96th wk. ADAS-cog showed similar findings. Maximum improvement was found around week 24. In conclusion, the effect of KRG on cognitive functions was sustained for 2 yr follow-up, indicating feasible efficacies of long-term follow-up for Alzheimer's disease.

Keywords

References

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