Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Dietary Fiber Isolated from Synurus deltoides on Constipation in Loperamide-Induced Rats

수리취 식이섬유가 Loperamide로 유발된 변비에 미치는 영향

  • Park, Min-Hee (Gangwon Agricultural Research and Extention Services) ;
  • Kwon, Chang-Ju (Gangwon Agricultural Research and Extention Services) ;
  • Lim, Sang-Hyun (Gangwon Agricultural Research and Extention Services) ;
  • Kim, Kyung-Hee (Gangwon Agricultural Research and Extention Services) ;
  • Heo, Nam-Ki (Gangwon Agricultural Research and Extention Services) ;
  • Jang, Hyung-Kwan (Dept. of Veterinary Medicine, Chonbuk National University) ;
  • Park, In-Jae (Dept. of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Kwang-Jae (Gangwon Agricultural Research and Extention Services)
  • Received : 2011.10.07
  • Accepted : 2011.12.01
  • Published : 2011.12.31
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Abstract

The effects of dietary fiber isolated from Synurus deltoides on constipation induced by loperamide (4 mg/kg/day) were investigated. Food intake and body weight both decreased in the 5% S. deltoides dietary fiber and loperamide-treated group (SD5) and 10% S. deltoides dietary fiber and loperamide-treated group (SD10), whereas fecal water contents increased by 2.4 and 3.4-fold in the SD5 and SD10 groups, respectively. The concentrations of total-cholesterol, HDL-cholesterol and triglyceride in the sera of the SD5 and SD10 groups were lower than those in the control (C) group. However, the biochemical parameters, GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), and glucose levels, were not affected by the level of S. deltoides. In addition, the concentrations of total-cholesterol and triglyceride in the livers of the SD5 and SD10 groups were also significantly lower than those in the control group. These results suggest that dietary fiber isolated from S. deltoides might ameliorate constipation symptoms, and lower lipid concentrations in the blood and liver.

새로운 식이섬유 소재 발굴을 위하여 수리취 식이섬유의 변비 개선 효능을 검정한 결과, 흰쥐의 사료섭취량과 체중 변화는 정상군에 비해 수리취 식이섬유 투여군이 유의적으로 낮아 식욕억제와 비만예방에 효과가 있을 것으로 사료된다. 분변의 수분함량은 수리취 식이섬유 급이 시 식이섬유 첨가량에 따라 각각 2.4배 및 3.4배 증가하였으며, 간과 신장의 무게는 각 군간 차이가 없어 수리취 유래 식이섬유는 10% 농도에서 간과 신장에 독성이 없는 것으로 판단된다. 수리취 식이섬유 10% 급이 시 혈중 total-cholesterol, HDL-cholesterol 및 중성지방은 감소하였으며, 간 조직 내 지질농도는 혈중 지질농도와 마찬가지로 total-cholesterol 및 중성지방은 정상군 및 대조군에 비해 수리취 식이섬유 투여군에서 감소하였고, HDL-cholesterol 농도는 대조군에 비해 높아지는 경향을 보였으나 유의차는 없었다. 이와 같은 결과로 보아 수리취 식이섬유는 식욕을 억제하고 혈중 지질의 농도를 감소시키며 변비의 증상을 개선하는 효과가 있는 것으로 사료된다.

Keywords

References

  1. Muller-Lissner SA. 1999. Classification, pharmacology, and side effects of common laxatives. Ital J Gastroenterol 31: 234-237.
  2. Mo SM, Lee YS, Loo JO, Shon SM, Seo JS, Yoon EY, Lee SK, Kim WK. 2002. Dietetic therapy. Kyomunsa, Seoul, Korea. p 327.
  3. Yim MY, Jang SA, Lee SG, Ly SY. 2003. Effects of psyllium husk and glucomannan on serum lipids, fecal fat excretion and body fat in rats fed high-fat diet. J Korean Soc Food Sci Nutr 32: 469-473. https://doi.org/10.3746/jkfn.2003.32.3.469
  4. Poller L. 1970. Fiber and diabetes. Lancet 24: 434-435.
  5. Lee JJ, Park MR, Kim AR, Lee MY. 2011. Effects of ramie leaves on improvement of lipid metabolism and anti-obesity effect in rats fed a high fat/high cholesterol diet. Korean J Food Sci Technol 43: 83-90. https://doi.org/10.9721/KJFST.2011.43.1.083
  6. Jun DW, Park HY, Lee OY, Lee HL, Yoon BC, Choi HS, Hahm JS, Lee MH, Lee DH, Kee CS. 2006. A populationbased study on bowel habits in a Korean community: prevalence of functional constipation and self-reported constipation. Dig Dis Sci 51: 1471-1477. https://doi.org/10.1007/s10620-006-9087-3
  7. Wald A, Scarpignato C, Kamm MA, Mueller-Lissner S, Helfrich I, Schuijt C, Bubeck J, Limoni C, Petrini O. 2007. The burden of constipation on quality of life: results of a multinational survey. Aliment Pharmacol Ther 26: 227-236. https://doi.org/10.1111/j.1365-2036.2007.03376.x
  8. Im JH, Choi JK, Lee MH, Ahn YT, Lee JH, Huh CS, Kim GB. 2011. Effect of functional yogurt (R&B Rhythm) on the improvement of constipation in animal models. Korean J Food Sci Ani Resour 31: 442-450. https://doi.org/10.5851/kosfa.2011.31.3.442
  9. Lembo A, Camilleri M. 2003. Chronic constipation. N Engl J Med 349: 1360-1368. https://doi.org/10.1056/NEJMra020995
  10. Schneeman BO. 1989. Dietary fiber. Food Technol 43: 133-136.
  11. Park EY, Lee SS. 1996. Effect of dietary fiber on the serum lipid level and bowel function in aged rats. Korean J Nutr 29: 934-942.
  12. Lee HJ, Hwang EH. 1997. Effects of alginic acid, cellulose and pectin level on bowel function in rats. Korean J Nutr 30: 456-477.
  13. Krotkiewski M. 1987. Effect of guar gum on the arterial blood pressure. Acta Med Scand 222: 738-746.
  14. Saltzman E, Moriguti JC, Das SK, Corrales A, Fuss P, Greenberg AS, Roberts SD. 2001. Effects of a cereal rich in soluble fiber on body composition and dietary compliance during consumption of a hypocaloric diet. J Am Coll Nutr 20: 50-57. https://doi.org/10.1080/07315724.2001.10719014
  15. Kay RM, Truswell AS. 1977. Effect of citrus pectin on blood lipids and fecal steroid excretion in man. Am J Clin Nutr 30: 171-174. https://doi.org/10.1093/ajcn/30.2.171
  16. Kang HJ, Song YS. 1997. Dietary fiber and cholesterol metabolism. J Korean Soc Food Sci Nutr 26: 358-369.
  17. Kang HS, Lee YS, Park YJ. 1998. Effect of indigestible dextrin on large intestinal functions and fecal states of rats. Korean J Nutr 31: 991-998.
  18. Ebihara K, Nakamoto Y. 1998. Comparative effect of watersoluble and insoluble dietary fiber on bowel function in rats fed a liquid elemental diet. Nutr Res 18: 883-891. https://doi.org/10.1016/S0271-5317(98)00073-6
  19. Ham SS, Han HS, Choi KP, Oh DH. 1997. Inhibitory effects of Synurus deltoides extacts on the mutagenesis induced by various mutagens. J Korean Soc Food Sci Nutr 26: 528-533.
  20. Park JH, Son KH, Kim SW, Chang HW, Bae K, Kang SS, Kim HP. 2004. Anti-inflammatory activity of Synurus deltoides. Phytother Res 18: 930-933. https://doi.org/10.1002/ptr.1595
  21. Lee KJ, Yun IJ, Kim HY, Kim KH, Kim YJ, Kim DW, Lim SH. 2010. Antioxidative activities of solvent extracts from of Synurus excelsus and Synurus palmatopinnatifidus. J Korean Soc Food Sci Nutr 39: 1893-1897. https://doi.org/10.3746/jkfn.2010.39.12.1893
  22. Jung MJ, Heo SI, Wang MH. 2008. Antioxidant activities of different parts of Synurus deltoides Nakai extracts in vitro. Food Sci Biotechnol 17: 1156-1159.
  23. AOAC. 1995. Total, soluble and insoluble dietary fiber in food. AOAC official method 991.43. Official Methods of Analysis. 16th ed. Washington, DC, USA.
  24. Lee JJ, Lee YM, Jung SK, Kim KY, Lee MY. 2008. Effect of dietary mulberry leaf on loperamide-induced constipation in rats. Korean J Food Preserv 15: 280-287.
  25. Shimotoyodome A, Yajima N, Suzuki J, Tokimitsu I. 2005. Effects of coingestion of different fibers on fecal excretion and cecal fermentation in rats. Nutr Res 25: 1085-1096. https://doi.org/10.1016/j.nutres.2005.09.018
  26. Salvin JL. 1994. Epidemiological evidence for the impact of whole grains on health. Crit Rev Food Sci Nutr 34: 427-434. https://doi.org/10.1080/10408399409527672
  27. Kim MH. 2000. The water-soluble extract of chicory reduces cholesterol uptake in gut-perfused rats. Nutr Res 20: 1017-1026. https://doi.org/10.1016/S0271-5317(00)00192-5
  28. Lee JS, Lee MH, Koo JG. 2010. Effect of porphyran and insoluble dietary fiber isolated from laver, Porphyra yezoensis, on lipid metabolism in rats fed high fat diet. Korean J Food & Nutr 23: 562-569.
  29. Hong SS, Cha JY, Kim DJ. 2002. Effect of psyllium husk, pectin and cellulose on the lipid concentrations and hemobiochemical enzymes in rats. J Korean Soc Food Sci Nutr 32: 808-813. https://doi.org/10.3746/jkfn.2002.31.5.808
  30. Lee JH, Park KS. 1999. Effect of Ganoderma lucidum on the liver function and metabolism in alcohol-consuming rats. Korean J Nutr 32: 519-525.
  31. Vahouny PH, Roy T, Callo LL, Story JA, Kritchevsky D, Cassidy MM. 1980. Dietary fibers III. Effects of chronic intake on cholesterol absorption and metabolism in the rats. Am J Clin Nutr 33: 2182-2191. https://doi.org/10.1093/ajcn/33.10.2182
  32. Kim MJ, Jang JY, Lee MK, Park JY, Park EM. 1999. Effect of fiber on lipid concentration in hypercholesterolemic rats. Korean J Food & Nutr 12: 20-25.

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