Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Antihyperlipidemia and Antiarteriosclerosis of Hizikia fusiformis in Sprague-Dawley Rats

톳(Hizikia fusiformis)의 Sprague-Dawley계 흰쥐에서 항고지혈증 및 항동맥경화증 효능

  • Lee, Seung-Joo (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Yim, Mi-Jin (Marine Bio Regional Innovation Center) ;
  • Kim, Gwang-Woo (Faculty of Fisheries Sciences, Hokkaido University, Hakodate) ;
  • Cho, Soon-Yeong (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Choi, Jong-Won (College of Pharmacy, Kyungsung University,)
  • 이승주 (강릉원주대학교 식품가공유통학과) ;
  • 임미진 (동해안해양생물자원연구센터) ;
  • 김광우 (북해도대학교 수산과학연구원) ;
  • 조순영 (강릉원주대학교 식품가공유통학과) ;
  • 최종원 (경성대학교 약학대학)
  • Received : 2011.08.08
  • Accepted : 2011.09.30
  • Published : 2011.10.31
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Abstract

The effects of dietary supplementation with Hizikia fusiformis on anti-hyperlipidemic activities were investigated in an animal study in which normal rats were fed Hizikia fusiformis, Hizikia fusiformis ethanol extract and Hizikia fusiformis ethanol extract residue. Serum total lipid and triglyceride levels were significantly (P<0.05) reduced in rats fed Hizikia fusiformis ethanol extract residue at a dose of 200 mg/kg body weight when compared to hyperlipidemic control rats. There were also significant decreases in serum total cholesterol and LDL-cholesterol levels in the rats fed Hizikia fusiformis ethanol extract residue at 200 mg/kg body weight. In addition, the atheroscrelosis index and superoxide dismutase in blood lipids were significantly (P<0.05) lowered in rats fed Hizikia fusiformis ethanol extract residue at 200 mg/kg body weight, as compared to control rats. In conclusion, Hizikia fusiformis and Hizikia fusiformis ethanol extract residue had beneficial antihyperlipidemic and antiarteriosclerosis effects.

Keywords

References

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