Journal of the Korean Crystal Growth and Crystal Technology (한국결정성장학회지)

The Korea Association of Crystal Growth (한국결정성장학회)
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Intercalation behavior study of ibuprofen/clay organic-inorganic nanocomposites as drug release system

약물 방출 시스템으로서 이부프로펜/클레이 유-무기 나노복합체의 층간삽입 거동 연구

  • Choi, Bong-Seok (School of Materials Science Engineering, Pusan National University) ;
  • Kim, Dong-Hyun (School of Materials Science Engineering, Pusan National University) ;
  • Kim, Tae-Wan (School of Materials Science Engineering, Pusan National University) ;
  • Jin, Heoyng-Ho (School of Materials Science Engineering, Pusan National University) ;
  • Park, Hong-Chae (School of Materials Science Engineering, Pusan National University) ;
  • Yoon, Seog-Young (School of Materials Science Engineering, Pusan National University)
  • Received : 2011.10.28
  • Accepted : 2011.11.18
  • Published : 2011.12.31
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Abstract

This research focused on the intercalation behavior of recrystallized ibuprofen into clay as a sustained release drug carrier. The intercalation behaviors of ibuprofen were determined by X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The basal spacing ($d_{001}$) of clay increased from 1.2 nm to 1.5 nm by ibuprofen molecules. The segmental motion effect of ibuprofen into the clay interlayer spacing also increased the thermal stability of the ibuprofen/clay nanocomposites. The in vitro drug release results of nanocomposites showed that ibuprofen was released from clay steadily.

본 연구는 지속적 약물방출 전달체로서의 클레이 내의 재결정화 된 이부프로펜 층간삽입 거동에 대해 주안점을 두었다. 이부프로펜의 층간삽입 거동은 X-선 회절 및 열 중량 분석을 통해 확인하였다. 클레이의 기저 공간은 이부프로펜 분자에 의해 1.2 nm에서 1.5 nm까지 증가하였다. 또한 클레이 내부 공간 층에 존재하는 이부프로펜의 부분 운동은 이부프로펜/클레이 나노복합체의 열적 안정성을 증가시켰다. 나노복합체의 in vitro 약물방출 결과는 이부프로펜이 클레이로부터 일정하게 방출됨을 보였다.

Keywords

References

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