Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
권호 표지

Single Oral Dose Toxicity of TB001 in Rats

백서에서 식품 복합물 TB001의 단회 경구투여 독성 시험 연구

  • Cha, Yun-Yeop (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Sang-Ji University) ;
  • Sun, Seung-Ho (Dept. of Oriental internal Medicine, College of Oriental Medicine, Sang-Ji University) ;
  • Park, Won-Hyung (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Sang-Ji University) ;
  • Park, Dong-Sik (Functional Food and Nutrition Division, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Jae-Hyun (Functional Food and Nutrition Division, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Hee-Yeon (Gangwon Provincial Agricultural Research & Extention Services) ;
  • Lim, Sang-Hyun (Gangwon Provincial Agricultural Research & Extention Services) ;
  • Kim, Kyung-Hee (Gangwon Provincial Agricultural Research & Extention Services)
  • 차윤엽 (상지대학교 한의과대학 한방재활의학과교실) ;
  • 선승호 (상지대학교 한의과대학 한방내과학교실) ;
  • 박원형 (상지대학교 한의과대학 한방재활의학과교실) ;
  • 박동식 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 김재현 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 김희연 (강원도 농업기술원 농산물이용시험장) ;
  • 임상현 (강원도 농업기술원 농산물이용시험장) ;
  • 김경희 (강원도 농업기술원 농산물이용시험장)
  • Received : 2011.09.14
  • Accepted : 2011.10.05
  • Published : 2011.10.30
⟨ Previous Next ⟩

Abstract

Objectives: This study was performed to investigate single oral dose toxicity of TB001, the extract mixture of Purple loosestrife and Aceriphyllum rossii. Methods: The mortality, general symptom, change of weight: and necropcy findings was investigated for 14 days after a dose(2000 mg/kg B.W.) of TB001 was given, using SD rats of both male and female according to "The guideline of toxicity test for medicine and others". Results: The death of rats and abnormal finding was not observed. There was no the significant difference of weight between control group and TB001 group. Conclusions: The abnormalities at the necropsy finding of all survived rats was not detected. The study suggested that there is no toxicity in single dose(2000 mg/kg B.W.) of TB001.

Keywords

Acknowledgement

Supported by : 농촌진흥청

References

  1. Ahn IS, Park KY, Do MS. Weight control mechanisms and anti-obesity functional agents. Journal of Korean Society Food Science Nutrition. 2007;36:503-13. https://doi.org/10.3746/jkfn.2007.36.4.503
  2. Lee HJ, Chung MJ, Kim DJ, Choe M. Effects of Oenanthe javanica, Coicis lachryma-jobi L. var. and Plantaginis asiatica L. water extracts on activities of key enzyme on lipid metabolism. Journal of Korean Society Food Science Nutrition. 2009;38:1516-21. https://doi.org/10.3746/jkfn.2009.38.11.1516
  3. Lee TB. Coloured flora of Korea. Hyangmunsa. 2006:792.
  4. Kim SM, Lee SW. The bibliographical study on the famine relief food of chosun-dynasty. Journal of the East Asian of Dietary Life. 1992;2:35-55.
  5. http://fse.foodnara.go.kr/orison.
  6. Ahn EM, Han JT, Kwon BM, Kim SH, Baek NI. Anti-cancer activity of flavonoids from Aceriphyllum rossii. J Korean Soc Appl Biol Chem. 2008;51:309-15. https://doi.org/10.3839/jksabc.2008.054
  7. 식품의약품안전청. 의약품등의독성시험기준(식품의약품안전청고시 제 2009-116호(2009년 8월 24일). 2009.
  8. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1991-2000. JAMA. 2002;288(14):1723-7. https://doi.org/10.1001/jama.288.14.1723
  9. James WP. What are the health risk? The medical consequences of obesity and its health risks. Exp Clin Endocrinol Diabetes. 1998;106(2):1-6.
  10. Poston WS 2nd, Foreyt JP, Borrell L, Haddock CK. Challenges in obesity management. South Med J. 1998;9(8):267-82.
  11. Lee S, So S, hwang E, Koo B, han G, Ko S, Kim N. Effect of Ginseng and herbal plant mixture on anti-obesity in obese SD rat induced by high fat diet. Journal of Korean Society Food Science Nutrition. 2008;37:437-44. https://doi.org/10.3746/jkfn.2008.37.4.437
  12. Takhtajan A. Diversity and classification of flowering plants. New York:Columbia University Press. 1967:284.
  13. Thnalier Z, Kosar M, Kupeli E, Calis I, Baser KHC. Antioxidant, anti-inflammatory, anti-nociceptive activities and composition of Lythrum salicaria L. extracts. Journal of Ethnopharmacology. 2007;110:539-47. https://doi.org/10.1016/j.jep.2006.10.024
  14. Becker H, Scher JM, Speakman JB, Zapp J. Bioactivity guided isolation of antimicrobial compounds from Lythrum salicaria. Fitoterapia. 2005;7:580-4.
  15. Lee SE, Park CG, Ahn YS, Son YD, Cha SS, Seong NS. Antioxidative and hepatoprotective effects of Lythrum salicaria. Korean Journal of Medicinal Crop Science. 2009;17:1-7.
  16. Lee SE, Ahn TJ, Kim GS, Kim YO, Han HS, Seo JS, Chung HY, Park CB, Cha SW, Park SW, Park, HK, Seong NS. Antioxidative and anti-fibrotic properties of root extracts of Lythrum salicaria L. in CCL4-induced liver fibrosis rat model. Korean Journal of Medicinal Crop Science. 2009;17:243-50.
  17. Choi OJ. Component and use of medicinal plants. Irwolseogak. 1999:486.
  18. Lee SE, Park CG, Ahn YS, Son YD, Cha SS, Seong NS. Antioxidative and hepatoprotective effects of Lythrum salicaria. Korean Journal of Medicinal Crop Science. 2009;17:1-7.
  19. Lee WT. In Standard illustration of Korean Plants: Aceriphyllum rossii. 1st ed. Seoul Korea:Academy Press. 1996.
  20. Min BS, Lee IS, Chang MJ, Yoo JK, Na NK, Hung TM, Thoung PT, Lee JP, Kim, JH, Kim JC, Woo MH, Choi JS, Lee HK, Bae KH. Anticomplementary activity of triterpenoids from the whole plant of Aceriphyllum rossii against the classical pathway. Planta Medica. 2008;74:726-9. https://doi.org/10.1055/s-2008-1074534
  21. Lee IS, Yoo JK, Na MK, Min BS, Lee JP, Yun BS, Jin WY, Bae KH. Cytotoxity of triterpenes isolate from Aceriphyllum rossii. Chem Pharm Bull. 2007;55:1376-8. https://doi.org/10.1248/cpb.55.1376
  22. Ahn EM, Han JT, Kwon BM, Kim SH, Baek NI. Anti-cancer activity of flavonoids from Aceriphyllum rossii. J Korean Soc Appl Biol Chem. 2008;51:309-15. https://doi.org/10.3839/jksabc.2008.054
  23. Lee CH, Lee JH, Heo CS. ${\Beta}$-site amyloid precursor protein cleaving enzyme inhibitory activity of Aceriphyllum rossii Korea Patent. 2007:10-2007-0022745.
  24. Lee HS, Lee CH, Kim YK, No MC, Park HL, Seo JH, Choi L, Yoo MY. Metabolic pharmaceutical composition comprising Aceriphyllum rossii extract and active compound isolated from them. Korea Patent. 2008:10-2008-0002433.
  25. Han JT, Kim HY, Park YD, Lee YH, Lee KR, Kwon BM, Baek NI. Aceriphyllic acid A, a new ACAT inhibitory triterpenoid from Aceriphyllum rossii. Planta Media. 2002;68:558-61. https://doi.org/10.1055/s-2002-32565
  26. Han JT, Bang MH, Chun OK, Kim DO, Lee CY, Baek NI. Flavonol glycoside, from the aerial parts of Aceriphyllum rossii and their antioxidant activities. Arch Pharm Res. 2004;27:390-5. https://doi.org/10.1007/BF02980079