The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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The Effects of Magnoliae officinalis Cortex and Machili thunbergii Cortex on Small Intestinal Motility

후박(厚朴)과 토후박(土厚朴)의 소장운동에 미치는 영향에 대한 연구

  • Lee, Kyung-Jin (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Geun-Yong (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Gyu-Ha (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Liu, Kwang-Hyeon (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University) ;
  • Kim, Tae-Wan (Dept. of Physiology, College of Veterinary Medicine Kyungpook National University) ;
  • Ham, In-Hye (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Bu, Young-Min (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Ho-Young (Department of Herbology, College of Oriental Medicine, Kyung Hee University)
  • 이경진 (경희대학교 한의과대학 본초학교실) ;
  • 박근용 (경희대학교 한의과대학 본초학교실) ;
  • 박규하 (경희대학교 한의과대학 본초학교실) ;
  • 류광현 (경북대학교 약학대학) ;
  • 김태완 (경북대학교 수의과대학 생리학교실) ;
  • 함인혜 (경희대학교 한의과대학 본초학교실) ;
  • 부영민 (경희대학교 한의과대학 본초학교실) ;
  • 최호영 (경희대학교 한의과대학 본초학교실)
  • Received : 2011.11.01
  • Accepted : 2011.12.16
  • Published : 2011.12.30
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Abstract

Objectives : Magnoliae officinalis Cortex (MOC) has been used in traditional medicine for digestive diseases in Korea, China and Japan. However, Machili thunbergii Cortex (MTC) also has been used as a substitute of MOC in Korea sometimes. Thus, this study was carried out to investigate and compare the effects of MOC and MTC on intestinal motility of isolated small intestinal segments from ICR mouse. Methods : Changes in motility were recorded via isometric transducers connected to a data acquisition system and amplitude, frequency and area under the curve (AUC) of intestinal spontaneous phasic contraction were compared. Results : The MOC extracts ($1{\sim}{\mu}g/mL$) dose-dependently decreased both amplitudes and frequencies of the spontaneous phasic contraction, but not AUC. However, high concentration of MOC (100 ${\mu}g$/mL) evoked tonic contraction. And it was not inhibited by tetrodotoxin, a sodium channel blocker, and nifedipine, a L-type $Ca^{2+}$ channel antagonist. These results suggested that MOC (100 ${\mu}g$/mL)-induced tonic contraction is not mediated by nerve or L-type $Ca^{2+}$ channel. On the other hand, the MTC extracts dose-dependently inhibited amplitude and AUC, but not the frequency. Conclusions : Although both MOC and MTC affected intestinal motility, MOC is more effective on intestinal motility than MTC. And MOC has been used as a traditional medicine for a long time but not MTC. Thus, we suggested that MTC should not be used in Korea as a substitute of MOC and MOC might be useful traditional medicine for gastrointestinal disease. The mechanism of MOC is still remained to elucidate.

Keywords

References

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