Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Evaluation of Antimicrobial Activity of the Methanol Extracts from 8 Traditional Medicinal Plants

  • Kang, Chang-Geun (Department of Pharmacology & Toxicology, College of Veterinary Medicine, Gyeongsang National University) ;
  • Hah, Dae-Sik (Gyeongnam Livestock Promotion Institute Middle-branch) ;
  • Kim, Chung-Hui (Department of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology) ;
  • Kim, Young-Hwan (Department of Microbiology & Immunology, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Eui-Kyung (Department of Pharmacology & Toxicology, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Jong-Shu (Department of Pharmacology & Toxicology, College of Veterinary Medicine, Gyeongsang National University)
  • Received : 2011.02.07
  • Accepted : 2011.02.15
  • Published : 2011.03.01
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Abstract

The methanol extract of 12 medicinal plants were evaluated for its antibacterial activity against Gram-positive (5 strains) and Gram-negative bacteria (10 strains) by assay for minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC). The antibacterial activity was determined by an agar dilution method (according to the guidelines of Clinical and Laboratory Standard Institute). All the compounds (12 extracts) of the 8 medicinal plants (leaf or root) were active against both Gram-negative and Gram-positive bacteria. Gram-negative showed a more potent action than Gram positive bacteria. The MIC concentrations were various ranged from $0.6\;{\mu}g/ml$ to $5000\;{\mu}g/ml$. The lowest MIC ($0.6\;{\mu}g/ml$) and MBC ($1.22\;{\mu}g/ml$) values were obtained with extract on 4 and 3 of the 15 microorganisms tested, respectively.

Keywords

References

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