Clinical and Experimental Reproductive Medicine

  • 제38권1호
  • /
  • Pages.6-9
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  • 2011
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility

  • Lee, Sun-Hee (Department of Biomedical Science, College of Life Science, CHA University) ;
  • Lee, Su-Man (Department of Biomedical Science, College of Life Science, CHA University)
  • 투고 : 2010.11.15
  • 심사 : 2011.01.01
  • 발행 : 2011.03.02
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초록

Objective: To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility. Methods: We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping. Results: The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155. Conclusion: The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility.

키워드

참고문헌

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피인용 문헌

  1. Mutations in the prostate specific antigen ( PSA / KLK3 ) correlate with male infertility vol.7, pp.None, 2011, https://doi.org/10.1038/s41598-017-10866-1
  2. Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception vol.103, pp.2, 2020, https://doi.org/10.1093/biolre/ioaa075
  3. Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations vol.10, pp.None, 2011, https://doi.org/10.1038/s41598-020-62584-w