Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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An adverse event following 2009 H1N1 influenza vaccination: a case of acute disseminated encephalomyelitis

  • Lee, Sang-Teak (Division of National Immunization Program and Vaccine Preventable Disease, Korea Centers for Control and Prevention) ;
  • Choe, Young-June (Division of National Immunization Program and Vaccine Preventable Disease, Korea Centers for Control and Prevention) ;
  • Moon, Won-Jin (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Choi, Jin-Woo (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Lee, Ran (Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine)
  • 투고 : 2011.01.05
  • 심사 : 2011.06.23
  • 발행 : 2011.10.15
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초록

Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that typically follows an infection or vaccination and has a favorable long-term prognosis. We describe the first reported case of ADEM after vaccination against novel influenza A (H1N1). A previously healthy 34-month-old boy who developed ADEM presented with a seizure and left-sided weakness 5 days after vaccination against novel influenza A (H1N1). Cerebrospinal fluid examination revealed elevated cell counts. T2-weighted images and fluid-attenuated inversion recovery images revealed multiple patchy hyperintense lesions in the frontal and parietal subcortical white matter and the left thalamus. After the administration of intravenous corticosteroid, the patient's clinical symptoms improved and he recovered completely without neurologic sequelae.

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참고문헌

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피인용 문헌

  1. A patient with both narcolepsy and multiple sclerosis in association with Pandemrix vaccination vol.321, pp.1, 2011, https://doi.org/10.1016/j.jns.2012.07.025
  2. Neurological complications after H1N1 influenza vaccination: magnetic resonance imaging findings vol.72, pp.7, 2014, https://doi.org/10.1590/0004-282x20140064
  3. Neurological events related to influenza A (H1N1) pdm09 vol.8, pp.3, 2014, https://doi.org/10.1111/irv.12241
  4. Post‐H1N1 vaccine acute disseminated encephalomyelitis vol.56, pp.3, 2014, https://doi.org/10.1111/ped.12148
  5. A spectrum of inflammation and demyelination in acute disseminated encephalomyelitis (ADEM) of children vol.14, pp.10, 2011, https://doi.org/10.1016/j.autrev.2015.06.002
  6. Acute Disseminated Encephalomyelitis After Influenza Vaccination: A Case Report vol.36, pp.3, 2011, https://doi.org/10.4037/ccn2016808