Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Topical Application of Herbal-mixed Extract on back skin suppresses inflammation in Ovalbumin-induced Atopic Dermatitis

아토피 피부염 동물모델에서 피부에 도포한 한약 복합추출물의 염증 억제 효과

  • Cho, Hee-Chan (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Sul, Hyun-Cheol (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Kim, Soon-Re (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Choi, Han-Seok (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Shin, Yong-Cheol (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Ko, Seong-Gyu (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
  • 조희찬 (경희대학교 한의과대학 예방의학교실) ;
  • 설현철 (경희대학교 한의과대학 예방의학교실) ;
  • 김순례 (경희대학교 한의과대학 예방의학교실) ;
  • 최한석 (경희대학교 한의과대학 예방의학교실) ;
  • 신용철 (경희대학교 한의과대학 예방의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실)
  • Received : 2011.11.15
  • Accepted : 2011.12.10
  • Published : 2011.12.31
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Abstract

Objective : This study is conducted to evaluate the efficiency of ethanol extracts of 4 mixed herbs(CP001 or CP002) on mouse model of atopic dermatitis induced by ovalbumin. Methods : Female BALB/c mice were internally sensitized with ovalbumin($20{\mu}g$) plus aluminum hydroxide hydrate(4mg) once per week. After 3 weeks, they were dermally challenged with patches containing ovalbumin ($100{\mu}g$) plus aluminum hydroxide hydrate(20mg) every other day for 3 weeks. After induction of atopic dermatitis, mice back skin were gently rubbed with CP001 or CP002(200mg/$m{\ell}$, $100{\mu}{\ell}$) for two weeks(every 2 days). Results : In CP001 or CP002 treated group, there was a remarkable reduction in infiltration of eosinophils on the skin areas and diminution of mast cells and total T cells in blood samples as compared with control group. Cutaneous expressions of interleukin-13, 17 were also decreased by CP001 or CP002. Moreover, blood immunoglobulin E level was decreased by drug administration while there was no decrease in OVA sensitization group. Conclusion : In summary, our result shows that herbal extracts(CP001 and CP002) could be potential candidates for the treatment of chronic atopic dermatitis.

Keywords

References

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