Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of Bee Venom on Propionibacterium acnes-induced inflammatory Skin Disease in Mice

봉독이 여드름 균으로 유도된 염증성 동물모델에 미치는 효과

  • Lee, Woo-Ram (Department of Pathology, Catholic University of Daegu) ;
  • Park, Ji-Hyun (Department of Pathology, Catholic University of Daegu) ;
  • Kim, Kyung-Hyun (Department of Pathology, Catholic University of Daegu) ;
  • An, Hyun-Jin (Department of Pathology, Catholic University of Daegu) ;
  • Han, Sang-Mi (Department of Agriculutal Biology, National Insititute of Agricultural Science and Technology) ;
  • Park, Kwan-Kyu (Department of Pathology, Catholic University of Daegu)
  • 이우람 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 박지현 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 김경현 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 안현진 (대구가톨릭대학교 의과대학 병리학교실) ;
  • 한상미 (농촌진흥청 농업과학기술원 농업생물부) ;
  • 박관규 (대구가톨릭대학교 의과대학 병리학교실)
  • Received : 2011.10.19
  • Accepted : 2011.12.05
  • Published : 2011.12.31
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Abstract

Bee venom (BV) has been used as a treatment for a wide variety of ailments such as inflammatory diseases in korean traditional medicine. Despite its well documented anti-inflammatory property, it has not been fully demonstrated regarding the influence of BV against Propionibactierium acnes (P. acnes), which promotes follicular inflammation (inflammatory acne). This study evaluated the anti-inflammatory property of BV against P. acnes in vivo. To induce inflammation in vivo using P. acnes, $1{\times}10^7$ CFU of living P. acnes were intradermally injected into the ear of mice. BV (1, 10, 100 ${\mu}g$) in vaseline was applied epicutaneously on the ear resulting in P. acnes-induced ear swelling and inflammation. Epicutaneous administration of BV with P. acnes decreased the number of infiltrated inflammatory cells and inflammatory cytokines in the ear, thereby relieving P. acnes-induced ear swelling and granulomatous inflammation, especially at the dose of 1 ${\mu}g$ of BV. In this report, we demonstrated the therapeutic effects of BV on P. acnes-induced inflammation in vivo using the mouse model. These data highlight the potential of using BV as an alternative treatment to the antibiotic therapy of acne vulgaris.

Keywords

References

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