Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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A New Antioxidant from the Marine Sponge-derived Fungus Aspergillus versicolor

  • Li, Jian Lin (College of Pharmacy, Pusan National University) ;
  • Lee, Yoon-Mi (College of Pharmacy, Pusan National University) ;
  • Hong, Jong-Ki (College of Pharmacy, Kyung Hee University) ;
  • Bae, Kyung-Sook (Korea Research Institute of Bioscience and Biotechnology) ;
  • Choi, Jae-Soo (Faculty of Food Science and Biotechnology, Pukyong National University) ;
  • Jung, Jee-H. (College of Pharmacy, Pusan National University)
  • Received : 2011.02.01
  • Accepted : 2011.03.18
  • Published : 2011.03.31
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Abstract

A chemical investigation of the marine-derived fungi Aspergillus versicolor led to the isolation of a new aromatic polyketide (1), The structure was elucidated by spectroscopic analysis, and its radical-scavenging activity, reducing power, and inhibitory activity to lipid oxidation were investigated. Those activities of compound 1 were compared with standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tertiarybutylhydroquinone (TBHQ), and ascorbic acid ($V_C$). Compound 1 showed antioxidant activity comparable to that of BHA, and siginificantly higher than that of BHT.

Keywords

References

  1. Amarowicz, R., Pegg, R.B., Rahimi-Moghaddam, B., Barl, B., and Weil, J. A., Free radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies. Food Chem., 84, 551-562 (2004). https://doi.org/10.1016/S0308-8146(03)00278-4
  2. Belofsky, G.N., Jensen, P.R., Renner, M.K., and Fenical, W., New cytotoxic sesquiterpenoid nitrobenzoyl esters from a marine isolate of the fungus Aspergillus versicolor. Tetrahedron, 54, 1715-1724 (1998). https://doi.org/10.1016/S0040-4020(97)10396-9
  3. Branen, A., Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene. J. Am. Oil Chem. Soc., 52, 59-63 (1975). https://doi.org/10.1007/BF02901825
  4. Duh, P., Tu, Y., and Yen, G., Antioxidant activity of water extract of Harng Jyur (Chrysanthemum morifolium Ramat). Lebensmittel-Wissenschaft und-Technologie, 32, 269-277 (1999). https://doi.org/10.1006/fstl.1999.0548
  5. Fremlin, L.J., Piggott, A.M., Lacey, E., and Capon, R.J., Cottoquinazoline A and cotterlosins A and B, metabolites from an Australian marinederived strain of Aspergillus versicolor. J. Nat. Prod. 72, 666-670 (2009). https://doi.org/10.1021/np800777f
  6. Hatano, T., Kagawa, H., Yasuhara, T., and Okuda, T., Two new flavonoids and other constituents in licorice root: their relative astringency and radical scavenging effects. Chem. Pharm. Bull., 36, 2090-2097 (1988). https://doi.org/10.1248/cpb.36.2090
  7. Imadia, K., Fukushima, S., Shirai, T., Ohtani, M., Nakanish, K., and Ito, N., Promoting activities of butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of $\gamma$-glutamyl transpeptidase-positive foci development in the liver of rats. Carcinogenesis, 4, 895-899 (1983). https://doi.org/10.1093/carcin/4.7.895
  8. Kumaran, A., Antioxidant and free radical scavenging activity of an aqueous extract of Coleus aromaticus. Food Chem., 97, 109-114 (2006). https://doi.org/10.1016/j.foodchem.2005.03.032
  9. Lee, Y.M., Dang, T.H., Hong, J., Lee, C.O., Bae, K.S., Kim, D.K., and Jung, J.H., A cytotoxic lipopeptide from the sponge-derived fungus Aspergillus versicolor. Bull. Korean Chem. Soc., 31, 205-208 (2010). https://doi.org/10.5012/bkcs.2010.31.01.205
  10. Lee, Y.M., Li, H., Hong, J., Cho, H.Y., Bae, K.S., Kim, M.A., Kim, D.K., and Jung, J.H., Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor. Arch. Pharm. Res., 33, 231-235 (2010). https://doi.org/10.1007/s12272-010-0207-4
  11. Lee, Y.M, Mansoor, T.A., Hong, J., Lee, C.O., Bae, K.S., and Jung, J.H., Polyketides from a sponge-derived fungus, Aspergillus versicolor. Nat. Prod. Sci., 13, 90-96 (2007).
  12. Lim, Y.J., Park, H.S., Im, K.S., Lee, C.O., Hong, J., Lee, Y.M., Kim, D.K., and Jung, J.H., Additional cytotoxic polyacetylenes from the marine sponge Petrosia species. J. Nat. Prod., 64, 46-53 (2001). https://doi.org/10.1021/np000252d
  13. Mojca, S., Petra, K., Majda, H., Aandreja, R., Maejana, R., and Knez, Z., Phenols, proanthocyanidins, flavones and flavonols in some plant materials and their antioxidant activities. Food Chem., 89, 191-198 (2005). https://doi.org/10.1016/j.foodchem.2004.02.025
  14. Oyaizu, M., Studies on products of the browning reaction. Antioxidative activities of browning reaction products prepared from glucosamine. Japanese J. Nutri. [Eiyogaku Zasshi], 44, 307-315 (1986). https://doi.org/10.5264/eiyogakuzashi.44.307
  15. Torel, J., Cillard, J., and Cillard, P., Antioxidant activity of flavonoids and reactivity with peroxy radical. Phytochemistry, 2, 383-385 (1986).
  16. Visioli, F., Bellomo, G., and Galli, C., Free radical-scavenging properties of olive oil polyphenols. Biochem. Biophy. Res. Commu., 247, 60-64 (1998). https://doi.org/10.1006/bbrc.1998.8735