Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antimicrobial Effects of Lonicera japonica against Gram Positive and Gram Negative Anaerobic Bacteria

  • Received : 2010.11.12
  • Accepted : 2011.02.19
  • Published : 2011.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

It has been shown that the butanol extract of Lonicera japonica has antimicrobial and other potentially useful biological activities. The purpose of this study was to determine the in vitro activity of Lonicera japonica compared to other antimicrobial agents against anaerobic bacteria. Specifically, the in vitro activity of the butanol extract was investigated against 104 clinical isolates of anaerobic bacteria using an agar dilution method and the results were compared to erythromycin, cefoxitin, imipenem, clindamycin, and metronidazole. It was found that Lonicera japonica and imipenem were the most active antimicrobial agents tested.

Keywords

References

  1. Byun, M.W., Jo, C., Jeon, T.W., and Hong, C.H., Effect of gamma irradiation on color characteristics and biological activities of extracts of Lonicera japonica (Japanese honeysuckle) with methanol and acetone. Lebensm.-Wiss. U. Technology. 37, 29-33 (2004).
  2. Cai, Y.Z., Luo, Q., Sun, M., and Croke, H., Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Science. 74, 2157-2184 (2004). https://doi.org/10.1016/j.lfs.2003.09.047
  3. Carl, E.N., Ann, L., and Ingela, P., Susceptibility of anaerobic bacteria to ALP 201. Antimicrob. Agents Chemother. 33, 2137-2139 (1989). https://doi.org/10.1128/AAC.33.12.2137
  4. Chang, C.W., Lin, M.T., Lee, S.S., Karin, C.S., Liu, C., and Hsu, F.L., Differential inhibition of reverse transcriptase and cellular DNA polymerase activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix. Antiviral Research. 27, 367-374 (1995). https://doi.org/10.1016/0166-3542(95)00020-M
  5. Holdeman, L.V., Cato, E.P., and Moore, W.E., Anaerobic laboratory manual, 4th ed. Virginia Polytechnic Institute and State University, Blacksburg. (1977).
  6. Kakuda, R., Imai, M., Yaoita, Y., Machida, K., and Kikuchi, M., Secoiridoid glycosides from the flower buds of Lonicera japonica. Phytochemistry. 55, 879-881 (2000). https://doi.org/10.1016/S0031-9422(00)00279-X
  7. Peng, L.Y., Mei, S.X., Jiang, B., Zhou, H., and Sun, H.D., Constituents from Lonicera japonica. Fitoterapia. 71, 713-715 (2000). https://doi.org/10.1016/S0367-326X(00)00212-4
  8. Rhee, K.H., Cyclic dipeptides exhibit synergistic, broad spectrum antimicrobial effects and have anti-mutagenic properties. Int. J. Antimicrob. Agents. 24, 423-427 (2004). https://doi.org/10.1016/j.ijantimicag.2004.05.005
  9. Shutter, V.L., Citron, D.M., and Finegold, S.M., Wadsworth anaerobic bacteriology manual, 3rd ed. The C. V. Mosby Co., St. Louis, Mo. (1980).
  10. Wang, H. and Helliwell, K., Determination of flavonols in green and black tea leaves and green tea infusions by high-performance liquid chromatography. Food Research International. 24, 223-227 (2001).
  11. Zhang, B., Yang, R., and Liu, C.Z., Microwave-assisted extraction of chlorogenic acid from flower buds of Lonicera japonica Thunb. Separation and Purification Technolog. 62, 480-483 (2008). https://doi.org/10.1016/j.seppur.2008.02.013