Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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The Study on toxicity and biological activities of Aconiti ciliare tuber Pharmacopuncture in Rats Original Articles

초오 약침 개발을 위한 백서 독성 연구 및 생리활성에 대한 연구

  • Kim, Sung-Chul (Dept. of Acupuncture and Moxibustion, Gwangju Oriental Medical Hospital, Wonkwang University) ;
  • Ahn, Seong-Hun (Dept. of Meridian & Acupoint, college of Oriental Medicine, Wonkwang University) ;
  • Kim, Sung-Ha (Dept. of Acupuncture and Moxibustion, Gwangju Oriental Medical Hospital, Wonkwang University) ;
  • Lee, Sang-Kwan (Dept. of Internal Medicine, Gwangju Oriental Medical Hospital, Wonkwang University) ;
  • Song, Bong-Keun (Dept. of Internal Medicine, Gwangju Oriental Medical Hospital, Wonkwang University)
  • 김성철 (원광대학교 광주한방병원 침구과) ;
  • 안성훈 (원광대학교 한의과대학 경혈학교실) ;
  • 김성하 (원광대학교 광주한방병원 침구과) ;
  • 이상관 (원광대학교 광주한방병원 한방내과) ;
  • 송봉근 (원광대학교 광주한방병원 한방내과)
  • Received : 2011.02.10
  • Accepted : 2011.03.07
  • Published : 2011.03.30
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Abstract

Objective : We investigate toxicity of Aconiti ciliare tuber and antioxidant activity of Aconiti ciliare tuber Pharmacopuncture to develop safe Aconiti ciliare tuber Pharmacopuncture and find out the effect. Methods : In order to investigate toxicity of Aconiti ciliare tuberm, we administered Aconiti ciliare tuberm orally to rats and examined the survival rate, comparing with the survival rate of rats administered by Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae. We examined the in vitro biological activity of Aconiti ciliare tuber Pharmacopuncture, including the total polyphenol content, and ABTS radical scavenging. Results and Conclusions : The $LD_{50}$ of Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae was 9.0g/kg, on the other hand, the $LD_{50}$ of Aconiti ciliare tuberm was more than 15g/kg. The total polyphenol contents of Aconiti ciliare tuberm Pharmacopuncture was 2.31mg/L. The 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) was 10.26%. We conclude that Aconiti ciliare tuberm is not highly toxic, Aconiti ciliare tuber Pharmacopuncture has a little antioxidant effect.

Keywords

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