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A Comparative Study of the Anti-Platelet Effects of cis- and trans-Resveratrol

  • Kim, Hwa (College of Pharmacy, Chonnam National University) ;
  • Oh, Seok-Jeong (College of Pharmacy, Chonnam National University) ;
  • Liu, Yingqiu (College of Pharmacy, Chonnam National University) ;
  • Lee, Moo-Yeol (College of Pharmacy, Chonnam National University)
  • Received : 2011.01.22
  • Accepted : 2011.02.07
  • Published : 2011.04.30

Abstract

Although various biological activities of resveratrol have been extensively studied, most reports have focused on trans-resveratrol and little attention has been paid to the cis-isomer. In this study, the effect of cis-resveratrol on platelet activity was examined and compared with that of the trans-isomer. Treatment with cis-resveratrol resulted in inhibition of platelet aggregation induced by thrombin, collagen or ADP, which are representative aggregation-inducing agents, and the trans-isomer elicited the same effects. These effects were concentration-dependent in the range of 1-100 ${\mu}M$. However, the potency of the cis-isomer was much lower than that of the trans-isomer; the $IC_{50}$ values for the cis-isomer versus the trans-isomer were $31{\pm}12$ vs $151{\pm}3$, $161{\pm}3$ vs $91{\pm}4$, and $601{\pm}15$ vs $251{\pm}6\;{\mu}M$ for thrombin-, collagen- and ADP-induced aggregation, respectively. These results indicate that cis-resveratrol has a less potent anti-platelet activity, compared with the trans-isomer, and raise the possibility that the biological activities of the cis-isomer may be different from those of the trans-isomer. It will be necessary to evaluate the activity of cis-resveratrol independently of the trans-isomer.

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