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Inhibitory Effects of Cultivated Wild Ginseng on the Differentiation of 3T3-L1 Pre-adipocytes

  • Mollah, Mohammad Lalmoddin (College of Natural Sciences, Sungshin Women's University) ;
  • Cheon, Yong-Pil (College of Natural Sciences, Sungshin Women's University) ;
  • In, Jun-Gyo (Natural Resources Research Institute, Korea Ginseng Corporation) ;
  • Yang, Deok-Chun (Korean Ginseng Center for Most Valuable Products & Ginseng Genetic Resource Bank, Kyung Hee University) ;
  • Kim, Young-Chul (College of Natural Sciences, Keimyung University) ;
  • Song, Jae-Chan (College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Kil-Soo (College of Veterinary Medicine, Kyungpook National University)
  • Received : 2010.09.30
  • Accepted : 2011.01.15
  • Published : 2011.03.29

Abstract

Wild ginseng has been used as a traditional medicine for thousands of years and for increase physical strength in Korea, China and Japan. This study reports that cultivated wild ginseng (CWG) inhibits adipocyte differentiation of 3T3-L1 pre-adipocytes in a concentration-dependent manner. Inhibition of adipocyte differentiation is one possible anti-obesity strategy. CWG inhibits the expression of the adipocyte differentiation regulator peroxisome proliferators-activated receptor (PPAR)${\gamma}$ and CCAAT/enhancer-binding protein ${\alpha}$mRNA. It also inhibited the expression of PPAR${\gamma}$ and adiponectin at the protein level during the differentiation of pre-adipocytes into adipocytes. Additionally, CWG blocked the cell cycle at the sub-$G_1$ phase transition, causing cells to remain in the pre-adipocyte state. These results indicate that CWG inhibits adipocyte differentiation and adipogenesis through pre-adipocyte cell cycle arrest in cultured 3T3-L1 cells.

Keywords

References

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