The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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The Effect of Direct Functional Magnetic Stimulation of the Lesion on Functional Motor Recovery in Spinal Cord Injured Rat

척수손상 흰 쥐의 운동기능 회복에 미치는 손상부위 직접자극을 통한 기능적 자기자극치료 효과

  • Cho, Yun-Woo (Department of Rehabilitation Medicine, College of Medicine, Yeungnam University) ;
  • Kim, Su-Jeong (Institute of Medical Science, Yeungnam University) ;
  • Park, Hea-Woon (Department of Rehabilitation Medicine, School of Medicine, Catholic University of Deagu) ;
  • Seo, Jeong-Min (Institute of Biomedical Engineering, Yeungnam University) ;
  • Hwang, Se-Jin (Department of Anatomy and Cell Biology, College of Medicine, Hanyang University) ;
  • Jang, Sung-Ho (Department of Rehabilitation Medicine, College of Medicine, Yeungnam University) ;
  • Lee, Dong-Gyu (Department of Rehabilitation Medicine, College of Medicine, Yeungnam University) ;
  • Ahn, Sang-Ho (Department of Rehabilitation Medicine, College of Medicine, Yeungnam University)
  • 조윤우 (영남대학교 의과대학 재활의학교실) ;
  • 김수정 (영남대학교 의과학연구소) ;
  • 박해운 (대구카톨릭대학교 의과대학 재활의학교실) ;
  • 서정민 (영남대학교 의료공학연구소) ;
  • 황세진 (한양대학교 의과대학 해부 및 세포생물학교실) ;
  • 장성호 (영남대학교 의과대학 재활의학교실) ;
  • 이동규 (영남대학교 의과대학 재활의학교실) ;
  • 안상호 (영남대학교 의과대학 재활의학교실)
  • Received : 2010.12.29
  • Accepted : 2011.02.07
  • Published : 2011.02.25
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Abstract

Purpose: The purpose of this study was to determine the effect of direct functional magnetic stimulation (FMS) of affected spinal cord on motor recovery following spinal cord injury in rats. Methods: After a contusion injury at the spinal level T9 using an NYU Impactor, functional magnetic stimulation was delivered by a magnetic stimulator through a round prototype coil (7 cm in diameter). Stimulation parameters were set as follows: repetition rate = 50 Hz (stimulus intensity 100% = 0.18 T), stimulation time = 20 min. Functional magnetic stimulation was administered twice a day, 5 days per week for 8 weeks starting 4 days after spinal cord injury. Functional magnetic stimulationwas delivered directly to the affected spinal cord. Outcomes of locomotor performance were assessed by the Basso Beattie Bresnahan (BBB) locomotor rating scale and by an inclined plane test weekly for 8 weeks. Results: In the BBB test, hindlimb motor function in the Functional magnetic stimulation group improved significantly more compared to the control group at 3, 4, 6, 7, and 8 weeks (p<0.05). In the inclined plane test, the angle of the plane in the functional magnetic stimulation group increased significantly more compared to the control group at 4, 5, 7, and 8 weeks (p<0.05). Conclusion: Our results demonstrate that direct Functional magnetic stimulation of the lesional site may have beneficial effects on motor improvement after spinal cord injury.

Keywords

References

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