Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Ovalbumin Induces Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression

Ovalbumin에 의한 cyclooxygenase-2와 inducible nitric oxide synthase 유도

  • Lee, A-Neum (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Park, Se-Jeong (Department of Medical Science, College of Medical Sciences, Soonchunhyang University) ;
  • Jeong, Ae-Ri (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Lee, Jae-Ran (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Park, Hye-Jeong (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Kim, Soo-Jung (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Min, In-Soon (Department of Healthcare Management, College of Medical Sciences, Soonchunhyang University) ;
  • Youn, Hyung-Sun (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University)
  • 이아늠 (순천향대학교 의료과학대학 임상병리학과) ;
  • 박세정 (순천향대학교 의료과학대학 의료과학과) ;
  • 정애리 (순천향대학교 의료과학대학 임상병리학과) ;
  • 이재란 (순천향대학교 의료과학대학 임상병리학과) ;
  • 박혜정 (순천향대학교 의료과학대학 임상병리학과) ;
  • 김수정 (순천향대학교 의료과학대학 임상병리학과) ;
  • 민인순 (순천향대학교 의료과학대학 보건행정경영학과) ;
  • 윤형선 (순천향대학교 의료과학대학 임상병리학과)
  • Received : 2010.09.03
  • Accepted : 2010.11.16
  • Published : 2011.02.28
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Abstract

Egg allergies are the most prevalent food hypersensitivity in children. The major egg allergens are proteins, such as ovalbumin (OVA) and ovomucoid (OVM), which are mainly contained in egg whites. OVA is the major protein in egg white, comprising 54% of the total protein content. OVA has been widely used in experimental inhalant and dietary allergy animal models, but its mechanism has not been clearly identified. In this study, we showed that OVA induced nuclear factor-${\kappa}B$ activation. OVA also induced the expression of cyclooxygenase-2 and inducible nitric oxide synthase. These data suggest new approaches for developing efficient anti-allergic strategies.

음식 알러지는 만성적인 장애를 일으킬 수 있는 즉각적이며 잠재적으로 생명을 위협하는 반응이다. 이 중 계란은 알러지 위험성이 높은 물질로, 아이들에게 음식 알러지를 유발하는 흔한 물질로 알려져 있다. 계란 알러젠 중에서 계란 흰자 단백질인 OVA이 주요한 알러젠으로 알려져 있다. 우리는 이번 연구에서 OVA이 염증 및 면역 반응에 중요한 역할을 한다고 알려져 있는 $NF-{\kappa}B$ 활성화와 COX-2와 iNOS 발현에 어떠한 영향을 미치는지를 알아보았다. OVA은 $NF-{\kappa}B$ 활성화와 COX-2와 iNOS의 발현을 증가시켰다. 이러한 연구는 앞으로 계란 알러젠에 의한 알러지 작용기전 규명 및 알러지 치료제 개발에 중요한 역할을 할 것으로 기대한다.

Keywords

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