- Volume 60 Issue 6
DOI QR Code
Principles and Medical Applications of Biomedical Photoacoustic Tomography
의료용 광음향 단층촬영 원리와 의학적 응용
- Received : 2011.05.08
- Accepted : 2011.05.18
- Published : 2011.06.01
Photoacoustics has been broadly studied in biomedicine, for both human and small animal tissues. Photoacoustics uniquely combines the absorption contrast of light or radio frequency waves with ultrasound resolution. Moreover, it is non-ionizing and non-invasive, and is the fastest growing new biomedical method, with clinical applications on the way. This paper provides a brief recap of recent developments in photoacoustics in biomedicine, from basic principles to applications. The emphasized areas include the new imaging modalities as well as translational research topics. A primary PA application in biomedicine is photoacoustic tomography (PAT). The past decade has seen fast developments in both theoretical reconstruction algorithms and innovative imaging techniques, and PAT has been implemented in imaging different tissues, from centimeter-large breast tumors to several micrometer-large single red blood cels (RBC). PAT now provides structural, functional and molecular imaging. Overall, PA techniques for biomedicine are maturing. They have been widely used to study both animal and human tissues. Recently, more and more research focuses on clinical applications. Commercialized PA systems are expected to be available in the near future, and wide clinical PA applications are foreseen.
Supported by : 한국연구재단
- Y. Wang, X. Xie, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica and L. V. Wang,"Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain", Nano Letters, Vol. 4, No. 9, pp 1689-1692, 2004 https://doi.org/10.1021/nl049126a
- J. Yang, K. Maslov, H. Yang, Q. Zhou, K. K. Shung and L. V. Wang, "Photoacoustic endoscopy," Optics Letters, Vol. 34, No. 10, 2009.
- C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley and L. V. Wang, "Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system," Biomedical Optics Express, Vol. 1, No. 1, 2010.
- X. Wang, X. Xie, G. Ku and L. V. Wang, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," Journal of Biomedical Optics. Vol. 11, 2006.
- S. Hu. K. Maslov and L. V. Wang, "In vivo functional chronic imaging of a small animal model using optical-resolution photoacoustic microscopy," Medical Physics Letter, Vol. 36, No. 6, 2009.
- M. Xu and L. V. Wang, "Photoacoustic imaging in biomedicine," Rev. Sci. Instrum. Vol. 77, pp. 041101, 2006. https://doi.org/10.1063/1.2195024
- E. Z. Zhang, J. G. Laufer, R. B. Pedley and P. C. Beard, "In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy," Physics In Medicine And Biology. Vol. 54, pp. 1035-1046, 2009. https://doi.org/10.1088/0031-9155/54/4/014
- http://en.wikipedia.org/ - Photoacoustic imaging in biomedicine
- http://labs.seas.wustl.edu/bme/Wang/presentations.html - Optical Imaging Laboratory at Washington University
- http://www.medphys.ucl.ac.uk/research/mle/ - Ucl Department Of Medical Physics And Bioengineering
- G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, L. V. Wang, "Thermoacoustic and Photoacoustic Tomography of Thick Biological Tissues Toward Breast Imaging" Technology in Cancer Research & Treatment, Vol. 4, Num.5, 2005.
- H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica and L. V. Wang, "Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy", Applied Physics Letters, Vol. 90, 2007.
- H. F. Zhang, K. Maslov, G. Stoica and L. V. Wang, "Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging". Nature Biotechnology 24, pp. 848 - 851, 2006. https://doi.org/10.1038/nbt1220
- http://www.chem.duke.edu/ - The Warren Rsesarch Group at Duke University
- M. Xu and L. V. Wang, "Universal back-projection algorithm for photoacoustic-computed tomography", Physical Review E71, 2005
- X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain", Nature Biotechnology 21, pp. 803-806, 2003. https://doi.org/10.1038/nbt839
- B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan and Q. Chen "Fast photoacoustic imaging system based on 320-element linear transducer array", Physics in Medicine and Biology 49, pp. 1339-1346, 2004. https://doi.org/10.1088/0031-9155/49/7/019
- Y. Sun, E. Sobel and H. Jiang, "Quantitative three-dimensional photoacoustic tomography of ther finger joints: an in vivo study", Journal of Biomedical Optics, Vol. 14(6), 2009.