Korean Chemical Engineering Research

The Korean Institute of Chemical Engineers (한국화학공학회)
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Principles of Simulated Moving Bed Reactor(SMBR)

Simulated Moving Bed Reactor(SMBR)의 원리

  • Song, Jae-Ryong (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University) ;
  • Kim, Jin-Il (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University) ;
  • Koo, Yoon-Mo (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University)
  • 송재룡 (인하대학교 생물공학과 초정밀생물분리기술연구센터) ;
  • 김진일 (인하대학교 생물공학과 초정밀생물분리기술연구센터) ;
  • 구윤모 (인하대학교 생물공학과 초정밀생물분리기술연구센터)
  • Published : 2011.04.30
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Abstract

Simulated Moving Bed(SMB) process consists of multiple chromatographic columns, which are usually partitioned into four zones. Such a process characteristic allows a continuous binary separations those are impracticable in conventional batch chromatographic processes. Compared with batch chromatography, SMB has advantages of continuity, high purity and productivity. Various researches have been reported for the integration of reaction and recovery during process operation on the purpose of economics and effectiveness. Simulated Moving Bed Reactor(SMBR) is introduced to combine SMB as a continuous separation process and reactor. Several cases of SMBR have been reported for diverse reactions with catalytic, enzymatic and chemical reaction on ion exchange resin as main streams. With an early type of fixed bed using catalyst, SMBR has been developed as SMB using fluidized enzyme, SMB with immobilized enzyme and SMB with discrete reaction region. For simple modeling and optimization of SMBR, a method considering convection only is possible. A complex method considering axial dispersion and mass transfer resistance is needed to explain the real behavior of solutes in SMBR. By combining reaction and separation, SMBR has benefits of lower installation cost by minimizing equipment use, higher purity and yield by avoiding the equilibrium restriction in case of reversible reaction.

SMB 공정은 주로 4개의 구역으로 나뉘어지는 다수의 크로마토그래피 컬럼으로 구성된다. 이러한 특성은 회분식 크로마토그래피 공정보다 우수한 이성분계 물질의 연속적인 분리를 구현한다. SMB는 회분식 크로마토그래피에 비해 연속성 및 높은 생산성과 순도로 목적물질을 분리해 낼 수 있는 장점을 갖는다. 경제적이며 효율적인 공정의 운용을 위해 반응과 회수를 결합시키는 연구가 보고되고 있으며, 이와 같은 연구 중 SMBR은 연속분리공정인 SMB와 반응기가 결합된 공정이다. 다양한 반응을 적용한 SMBR에 대해 많은 연구가 진행되고 있으며, 촉매반응, 효소반응, 이온 교환 수지를 통한 화학반응이 주를 이루고 있다. 초기의 SMBR은 촉매를 사용한 고정층의 형태이며, 유동성 효소를 사용하는 SMBR, 고정화 효소를 사용하는 SMBR, 반응구역과 흡착구역이 분리되어 있는 SMBR순으로 발전하였다. 공정 설계에 있어서 필수적인 모델링 및 최적화를 위하여 대류현상만을 고려한 간단한 기법이 있지만, 실제 물질거동을 설명하기 위해서는 축 방향 분산이나 물질전달 저항을 고려한 복잡한 해석을 필요로 한다. SMBR같이 반응과 분리가 결합된 공정의 경우 설비의 간소화를 통한 시설비용의 축소뿐 아니라 가역반응평형의 극복을 통해 물질의 순도와 수율을 향상시킬 수 있는 장점이 있다.

Keywords

References

  1. Shuler, M. L. and Kargi, F., Bioprocess engineering: Basic concepts, 2nd ed., Prentice Hall PTR., Upper Saddle River, NJ(2002).
  2. Harrison, R. G., Todd, P., Rudge, S. R. and Petrides, D. P., Bio- Separations Science and Engineering, 1st ed., Oxford University Press, New York, NY(2003).
  3. Broughton, D. B., "Molex Case History of A Process," Chem. Eng. Prog., 64(1), 60-72(1968).
  4. Broughton, D. B., Neuzil, R. W., Pharis, J. M. and Brearley, C. S., "The Parex Process for Recovering Paraxylene," Chem. Eng. Prog., 66(1), 70-82(1970).
  5. Ma, Z. and Wang, N.-H. L., "Standing Wave Analysis of SMB Chromatography: Linear Systems," AIChE J., 43(10), 2488-2508 (1997). https://doi.org/10.1002/aic.690431012
  6. Juza, M., Mazzotti, M. and Morbidelli, M. "Simulated Movingbed Chromatography and Its Application to Chirotechnology," Trends Biotechnol., 18(3), 108-118(2000). https://doi.org/10.1016/S0167-7799(99)01419-5
  7. Lee, C. H. and Koo, Y. M., "Simulated Moving Bed," Korean. J. Biotechnol. Bioeng., 20(3), 192-196(2005).
  8. Afonso, C. A. M. and Crespo, J. G., "Green Separation Processes: Fundamentals and Applications," 1st ed., Wiley-VCH., Weinheim, Germany(2005).
  9. Minceva, M., Gomes, P. S., Meshko, V. and Rodrigues, A. E., "Simulated Moving Bed Reactor for Isomerization and Separation of p-xylene," Chem. Eng. J., 140(1-3), 305-323(2008). https://doi.org/10.1016/j.cej.2007.09.033
  10. Pereira, C. S. M., Zabka, M., Silva, V. M. T. M. and Rodrigues, A. E., "A Novel Process for the Ethyl Lactate Synthesis in a Simulated Moving Bed Reactor (SMBR)," Chem. Eng. Sci., 64(14), 3301-3310(2009). https://doi.org/10.1016/j.ces.2009.04.003
  11. Meurer, M., Althehoner, U., Strube, J. and Schmidt-Traub, H., "Dynamic Simulation of Simulated Moving Bed Chromatographic Reactors," J. Chromatogr. A., 769(1), 71-79(1997). https://doi.org/10.1016/S0021-9673(96)00980-6
  12. Kulprathipanja, S., Reactive Separation Processes, 1st ed., Tayler & Francis, New York, NY(2002).
  13. Dinwiddie, J. A. and Morgan, W. A., "Fixes Bed Type Reactor," U.S. Patent No. 2,976,132(1961).
  14. Scott, C. D., Spence, R. D. and Sisson, W. G., "Pressurized, Annular Chromatograph for Continuous Separations," J. Chromutogr. A., 126(C), 381-400(1976). https://doi.org/10.1016/S0021-9673(01)84087-5
  15. Shieh, M. T. and Barker, P. E., "Combined Bioreaction and Separation in a Simulated Counter-Current Chromatographic Bioreactor- Separator for the Hydrolysis of Lactose," J. Chem. Tech. Biotechnol., 66(3), 265-278(1996). https://doi.org/10.1002/(SICI)1097-4660(199607)66:3<265::AID-JCTB503>3.0.CO;2-#
  16. Dunnebier, G., Fricke, J. and Klatt, K.-U. "Optimal Design and Operation of Simulated Moving Bed Chromatographic Reactors," Ind. Eng. Chem. Res., 39(7), 2290-2304(2000). https://doi.org/10.1021/ie990820o
  17. Hashimoto, K., Adachi, S., Noujima, H. and Ueda, Y., "New Process Combining Adsorption and Enzyme Reaction for Producing Higher-fructose Syrup," Biotechnol. Bioeng., 25(10), 2371-2393 (1983). https://doi.org/10.1002/bit.260251008
  18. Zhang, Y., Hidajat, K. and Ray, A. K., "Optimal Design and Operation of SMB Bioreactor: Production of High Fructose Syrup By Isomerization of Glucose," Biochem. Eng. J., 21(2), 111-121 (2004). https://doi.org/10.1016/j.bej.2004.05.007
  19. Borges da Silva, E. A., Ulson de Souza, A. A., de Souza, S. G. U. and Rodrigues, A. E., "Analysis of the High-fructose Syrup Production Using Reactive SMB Technology," Chem. Eng. J., 118(3), 167-181(2006). https://doi.org/10.1016/j.cej.2006.02.007
  20. Finkler, T. F., Kupper, A. and Engell, S., "Optimization of a Reactive SMB Process Applied to the Purification of Fructose Syrup," AIChE Annual Meeting., Nov, Nashville(2009).
  21. Toumi, A., Engell, S., Diehl, M., Bock, H. G. and Schloder, J., "Efficient Optimization of Simulated Moving Bed Processes," Chem. Eng. Proc., 46(11), 1067-1084(2007). https://doi.org/10.1016/j.cep.2006.06.026
  22. Toumi, A. and Engell, S., "Optimization-based Control of a Reactive Simulated Moving Bed Process for Glucose Isomerization," Chem. Eng. Sci., 59(18), 3777-3792(2004). https://doi.org/10.1016/j.ces.2004.04.009
  23. Kim, K., Kim, J. I., Kim, H., Yang, J., Lee, K. S. and Koo, Y. M., "Experimental Verification of Bilevel Optimizing Control for SMB Technology," Ind. Eng. Chem. Res., 49(18), 8593-8600(2010). https://doi.org/10.1021/ie1000218
  24. Natarajan, S. and Lee, J. H., "Repetitive Model Predictive Control Applied to a Simulated Moving Bed Chromatography System," Comp. Chem. Eng., 24(2-7), 1127-1123(2000). https://doi.org/10.1016/S0098-1354(00)00493-2
  25. Wang, C., Klatt, K.-U., Dunnebier, G., Engell, S. and Hanisch, F., "Neural Network-based Identification of SMB Chromatographic Processes," Control. Eng. Pra., 11(8), 949-959(2003). https://doi.org/10.1016/S0967-0661(02)00212-5
  26. Park, B. J., Lee, C. H., Mun, S. and Koo, Y. M., "Novel Application of Simulated Moving Bed Chromatography to Protein Refolding," Proc. Biochem., 41(5), 1072-1082(2006). https://doi.org/10.1016/j.procbio.2005.11.026
  27. Azevedo, D. C. S. and Rodrigues, A. E., "Design Methodology And Operation of a Simulated Moving Bed Reactor for the Inversion of Sucrose and Glucose-fructose Separation," Chem. Eng. J., 82(1-3), 95-107(2001). https://doi.org/10.1016/S1385-8947(00)00359-4
  28. Kruglov, A. V., "Methanol Synthesis in a Simulated Countercurrent Moving-bed Adsorptive Catalytic Reactor," Chem. Eng. Sci., 49(24 Part A), 4699-4716(1994). https://doi.org/10.1016/S0009-2509(05)80053-3
  29. Kawase, M., Inoue, Y., Araki, T. and Hashimoto, K., "The Simulated Moving-bed Reactor for Production of Bisphenol A," Catal. Today, 48(1-4), 199-209(1999). https://doi.org/10.1016/S0920-5861(98)00374-5
  30. Ganetsos, G. and Barker, P. E. (Eds.), "Preparative and Production Scale Chromatography," Marcel Dekker, New York, 375-394 (1993).