Journal of the Korean Data and Information Science Society

The Korean Data and Information Science Society (한국데이터정보과학회)
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Hyperlipidemia effect of garlic using mean difference of meta analysis

메타분석에서 평균차를 이용한 마늘의 항-고지혈증 효과

  • Yun, A-Reum (Department of Information and Statistics, Duksung Womens University) ;
  • Choi, Ki-Heon (Department of Information and Statistics, Duksung Womens University)
  • 윤아름 (덕성여자대학교 정보통계학과) ;
  • 최기헌 (덕성여자대학교 정보통계학과)
  • Received : 2011.02.10
  • Accepted : 2011.04.25
  • Published : 2011.05.31
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Abstract

The present study was carried out to summarize the effect of garlic in the hyperlipidemia rats by meta-analysis related studies. The association measure to test effect of garlic was the mean difference (MD). In this particular fixed-effect model of mean difference, body weight, liver weight, kidney weight and heart weight were significantly decreased (p < 0.05). Also, blood glucose, plasma total cholesterol, plasma triglycerides, LDL-cholesterol, liver cholesterol, liver triglycerides were significantly decreased. HDL-cholesterol was significantly increased. In this case of heterogeneous variable, random effect model was applied. In this model, liver weight, blood glucose, plasma total cholesterol, plasma triglycerides, LDL-cholesterol, liver cholesterol, liver triglycerides were significantly decreased. HDL-cholesterol was significantly increased. According to the meta-regression analysis, duration of injection was significantly for kidney weight, testis weight, plasma total cholesterol, plasma triglycerides, HDL-cholesterol, LDLcholesterol, liver cholesterol, liver triglycerides.

평균차를 이용한 메타분석을 실시하여 마늘을 투여한 고지혈증 유발 쥐들의 체중과 각 기관의 무게, 혈액 내 혈당량, 총 콜레스테롤, 중성지방, 고농도지단백 콜레스테롤, 저농도지단백 콜레스테롤, 간의 콜레스테롤, 간의 중성지방의 평균비교를 통해 마늘의 효과에 대해 알아보고자 한다. 고정효과 모형에서는 체중과 간, 신장, 심장의 무게에서 유의한 감소를 보였다. 또한 혈액 내 혈당량과 총 콜레스테롤, 중성지방, 저농도지단백 콜레스테롤, 간의 콜레스테롤, 간의 중성지방에서 통계적으로 유의한 감소를 보였고, 고농도지단백 콜레스테롤에서 유의한 증가를 보였다. 동질성 검정을 통해 연구 간의 이질성을 보인 모든 변수에 대해 랜덤효과모형을 적용시킨 결과 간의 무게와 혈액 내 혈당량, 총 콜레스테롤, 중성지방, 저농도지단백 콜레스테롤, 간의 콜레스테롤, 간의 중성지방의 감소에 유의한 효과를 보였고, 고농도지단백 콜레스테롤의 증가에 유의한 효과를 보였다. 또한 마늘의 투여기간이 변수에 영향을 미치는지 알아보기 위해 메타회귀분석을 실시한 결과 신장의 무게와 고환의 무게, 총 콜레스테롤, 중성지방, 고농도지단백 콜레스테롤, 저농도지단백 콜레스테롤, 간의 콜레스테롤, 간의 중성지방에 대해 마늘의 투여기간이 유의한 변수로 나타났다.

Keywords

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