Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Imatinib-Mesylate Induced Interstitial Pneumonitis in Two CML Patients

  • Kim, Tae-Hoon (Departments of Internal Medicine, Sanggye-Paik Hospital, Inje University College of Medicine) ;
  • Kim, Byung-Gyu (Departments of Internal Medicine, Sanggye-Paik Hospital, Inje University College of Medicine) ;
  • Cho, Sung-Woo (Departments of Internal Medicine, Sanggye-Paik Hospital, Inje University College of Medicine) ;
  • Cho, Sung-Kyun (Departments of Internal Medicine, Sanggye-Paik Hospital, Inje University College of Medicine) ;
  • Kim, Hyun-Jung (Departments of Pathology, Sanggye-Paik Hospital, Inje University College of Medicine) ;
  • Yuh, Young-Jin (Departments of Internal Medicine, Sanggye-Paik Hospital, Inje University College of Medicine) ;
  • Kim, Sung-Rok (Departments of Internal Medicine, Sanggye-Paik Hospital, Inje University College of Medicine)
  • Received : 2010.06.09
  • Accepted : 2010.07.27
  • Published : 2011.09.30
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Abstract

Imatinib mesylate, a selective inhibitor of BCR-ABL kinase activity, has demonstrated significant clinical efficacy in the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). It has become the standard of treatment for these diseases. Although the toxicity profile of imatinib is superior to that of interferon or other cytotoxic agents, some adverse events including edema, gastrointestinal toxicities and hematologic toxicities are commonly observed in the patients treated by imatinib. We present two cases of imatinib induced interstitial pneumonitis during the treatment of a chronic phase of CML.

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References

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