Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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The Effect of Low-intensity Pulsed Ultrasound on Osteogenesis in Mini-pig Mandibles

Mini-pig 하악골에서 저강도진동초음파가 골형성에 미치는 영향

  • Yun, Yeong-Eun (Department of Oral and Maxillofacial Surgery, Sun Dental Hospital) ;
  • Lee, Jun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Wonkwang University) ;
  • Min, Seung-Ki (Department of Oral and Maxillofacial Surgery, School of Dentistry, Wonkwang University) ;
  • Kim, Sang-Jung (Department of Oral and Maxillofacial Surgery, Sun Dental Hospital)
  • 윤영은 (선치과병원 구강악안면외과) ;
  • 이준 (원광대학교 치과대학 구강악안면외과학교실) ;
  • 민승기 (원광대학교 치과대학 구강악안면외과학교실) ;
  • 김상중 (선치과병원 구강악안면외과)
  • Received : 2011.07.12
  • Accepted : 2011.09.29
  • Published : 2011.11.30
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Abstract

Purpose: The objective of this study was to examine the affected period and the amount of bone formation during osteogenesis of intramembranous bone using low-intensity pulsed ultrasound (LPUS) $in$ $vivo$. Methods: Xeno-bone (Bio-oss) and autogenous bone were grafted bilaterally into mini-pig mandibles. The left mandible served as the control and the other mandible was treated with 3 MHz, 160 mW (output, 0.8 mW) ultrasound stimulation for 7 days 15 minutes per day. The mini-pigs were sacrificed at 1, 2, 4, and 8 weeks, and micro computed tomography (${\mu}CT$), a microscopic examination, and a statistical analysis were performed on the specimens. Results: Based on a computerized image analysis of the ${\mu}CT$ scans, the experimental group had an average 150% more new bone formation than that in the control group. The effect of LPUS continued during the post operative 2 weeks. The histomorphological microscopic examination showed similar results. Conclusion: Our results suggest the LPUS had an effect on early intramembranous bone formation in vivo.

Keywords

References

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