Archives of Plastic Surgery

  • 제38권4호
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  • Pages.351-358
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  • 2011
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
권호 표지

선택적 Cyclooxygenase-2 저해제 국소 도포가 토끼 귀의 창상반흔에 미치는 영향

The Effect of a Topical Selective Cyclooxygenase-2 Inhibitor on Skin-Wound Scarring of the Rabbit Ear

  • 김도엽 (고신대학교 의과대학 성형외과학교실) ;
  • 박진형 (고신대학교 의과대학 성형외과학교실) ;
  • 천봉권 (고신대학교 의과대학 병리학교실) ;
  • 한예식 (고신대학교 의과대학 성형외과학교실)
  • Kim, Do-Yup (Department of Plastic and Reconstructive Surgery, Kosin University College of Medicine) ;
  • Park, Jin-Hyung (Department of Plastic and Reconstructive Surgery, Kosin University College of Medicine) ;
  • Chun, Bong-Kwon (Department of Pathology, Kosin University College of Medicine) ;
  • Han, Yea-Sik (Department of Plastic and Reconstructive Surgery, Kosin University College of Medicine)
  • 투고 : 2010.12.06
  • 심사 : 2011.05.23
  • 발행 : 2011.07.10
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초록

Purpose: The inflammatory phase is considered an integral part of adult wound healing, but fetal wound healing studies have shown scarless healing results in the absence of the inflammation process. The COX-2 pathway is an essential component of inflammation. The purpose of this study is to identify the effect of a topical selective COX-2 inhibitor on inflammation in rabbit skin wound healing and scarring. Methods: Full-thickness wounds were made on 6 New Zealand rabbits' ears. Topical 5% celecoxib + vehicle (experimental tissue) and vehicle only (controlled tissue) were applied daily for 14d on each side of the ears. Scar samples were harvested at 2 wks, 4 wks, and 8 wks after the wounding. Each sample was stained with hematoxylin and eosin and the Masson's trichrome stain to evaluate inflammation and scar formation. Results: Histological analysis demonstrated a significant reduction of inflammation, neovascularization, and scar elevation in the experimental tissue as compared to the control. Additionally, experimental tissue exhibited faster improvement of collagen organization similar to that of normal tissue. Conclusion: This study suggests that the topical application of a selective COX-2 inhibitor on a rabbit ear wound resulted in decreased inflammation and had a positive effect on the reduction of scar formation.

키워드

참고문헌

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