Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Screening of α-Amylase, α-Glucosidase and Lipase Inhibitory Activity with Gangwon-do Wild Plants Extracts

강원도 자생 산채 추출물의 α-Amylase, α-Glucosidase, Lipase 효소 저해활성 탐색

  • Kim, Hee-Yeon (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Lim, Sang-Hyun (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Park, Yu-Hwa (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Ham, Hun-Ju (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Lee, Kwang-Jae (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Park, Dong-Sik (National Academy of Agricultural Science) ;
  • Kim, Kyung-Hee (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Kim, Song-Mun (Dept. of Biological Environment, Kangwon National University)
  • 김희연 (강원도농업기술원 농산물이용시험장) ;
  • 임상현 (강원도농업기술원 농산물이용시험장) ;
  • 박유화 (강원도농업기술원 농산물이용시험장) ;
  • 함헌주 (강원도농업기술원 농산물이용시험장) ;
  • 이광재 (강원도농업기술원 농산물이용시험장) ;
  • 박동식 (국립농업과학원) ;
  • 김경희 (강원도농업기술원 농산물이용시험장) ;
  • 김성문 (강원대학교 바이오자원환경학과)
  • Received : 2010.11.01
  • Accepted : 2010.12.15
  • Published : 2011.02.28
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Abstract

We investigated ${\alpha}$-amylase, ${\alpha}$-glucosidase and lipase inhibitory activity of extracts collected from wild plants in Gangwon-do. 90 wild plants were collected and their water and ethanol extracts were obtained. Results of measuring ${\alpha}$-amylase inhibitory activity indicated more than 80% of activity inhibition in 10 mg/mL concentration for ethanol extracts of three plants and water extracts of two plants. For ${\alpha}$-glucosidase inhibitory activity, ethanol extracts of thirteen plants and water extracts of three plants showed more than 80% of activity inhibition in 10 mg/mL concentration. In the experiment of inhibiting lipase activity, ethanol extracts of seven plants and water extracts of one plants showed above 80% of activity inhibition in 10 mg/mL concentration. These results suggest that the selected extracts could be potentially used as a resource of bioactive materials for health functional foods.

연구는 강원도 자생 산채류의 다양한 약리 기능 중 ${\alpha}$-glucosidase, ${\alpha}$-amylase, lipase 효소 저해활성이 우수한 식물소재를 탐색하는데 있다. 강원도 양구, 평창, 태백에서 자생하고 있는 산채 90종을 채집하여 물과 에탄올로 각각 추출하였다. 항비만 활성 탐색은 ${\alpha}$-amylase, ${\alpha}$-glucosidase, lipase 저해활성을 검정하였다. 그 결과 산채 90종 중 ${\alpha}$-amylase 활성 저해능이 높은 식물로 에탄올 추출물 3종, 물추출물 2종, ${\alpha}$-glucosidase 활성 저해능이 높은 식물로 에탄올 추출물 13종, 물 추출물 3종, lipase 활성 저해능이 높은 식물로 에탄올 추출물 7종, 물 추출물 1종이 선발되었다. 향후 본 연구결과는 비만과 당뇨 등 대사성 질환에 대해 예방 혹은 치료 효과가 있는 기능성식품으로 개발하는데 있어 좋은 기초자료로 활용될 것으로 기대된다.

Keywords

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