Proposed Mechanisms and Further study for Korean Traditional medicines-Drug Interaction in a view of Toxicology

한약의 약물상호작용 기전과 연구방향 - 독성학적인 측면을 중심으로 -

  • Park, Yeong-Chul (GLP Center, Catholic University of Daegu) ;
  • Kim, Myung-Dong (Dept. of Physiology, School of Oriental Medicine, Sangji University) ;
  • Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sangji University)
  • 박영철 (대구가톨릭대학교 GLP 센터) ;
  • 김명동 (상지대학교 한의과대학 생리학교실) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2011.04.10
  • Accepted : 2011.04.26
  • Published : 2011.04.30

Abstract

Objectives : The mechanisms for korean traditional medicine-drug interaction has not been well reviewed in spite that the chance for co-administration with western drugs or diet supplements has been increased. Especially, it is well known that various cytochrome P450s play a major role in drug-drug interaction. Of course, Korean traditional medicines is not excluded in a view of metabolism or biotransformation by cytochrome P450. This article was focused on reviewing the possible roles of cytochrome P450 in Korean traditional medicine-drug interaction, Also, the directions for further studies were suggested in terms of Korean traditional medicine-drug interaction. Methods : New studies for korean traditional medicine-drug interaction were reviewed and summarized in terms of cytochrome P450 activities by various Korean traditional medicines and western drugs. Results and Conclusions : Even if a few studies related to Korean traditional medicine-drug interactions was carried out, almost no studies for Korean traditional medicine-drug interactions has been found in a view of cytochrome P450. It was suggested that Korean traditional medicines and their decoction should be analyzed that how they effects on cytochrome P450, expecially CYP 1, 2, 3 families and how they interact with western drugs.

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