Proposed Mechanisms and Further study for Korean Traditional medicines-Drug Interaction in a view of Toxicology

한약의 약물상호작용 기전과 연구방향 - 독성학적인 측면을 중심으로 -

  • Park, Yeong-Chul (GLP Center, Catholic University of Daegu) ;
  • Kim, Myung-Dong (Dept. of Physiology, School of Oriental Medicine, Sangji University) ;
  • Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sangji University)
  • 박영철 (대구가톨릭대학교 GLP 센터) ;
  • 김명동 (상지대학교 한의과대학 생리학교실) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2011.04.10
  • Accepted : 2011.04.26
  • Published : 2011.04.30

Abstract

Objectives : The mechanisms for korean traditional medicine-drug interaction has not been well reviewed in spite that the chance for co-administration with western drugs or diet supplements has been increased. Especially, it is well known that various cytochrome P450s play a major role in drug-drug interaction. Of course, Korean traditional medicines is not excluded in a view of metabolism or biotransformation by cytochrome P450. This article was focused on reviewing the possible roles of cytochrome P450 in Korean traditional medicine-drug interaction, Also, the directions for further studies were suggested in terms of Korean traditional medicine-drug interaction. Methods : New studies for korean traditional medicine-drug interaction were reviewed and summarized in terms of cytochrome P450 activities by various Korean traditional medicines and western drugs. Results and Conclusions : Even if a few studies related to Korean traditional medicine-drug interactions was carried out, almost no studies for Korean traditional medicine-drug interactions has been found in a view of cytochrome P450. It was suggested that Korean traditional medicines and their decoction should be analyzed that how they effects on cytochrome P450, expecially CYP 1, 2, 3 families and how they interact with western drugs.

Keywords

References

  1. Mary L. Chavez, Melanie A. Jordan, Pedro I. Chavez, Evidence-based drug-. herbal interactions. Life Sciences. 2006 ; 78 : 2146-2157 https://doi.org/10.1016/j.lfs.2005.12.009
  2. Haller C. Clinical approach to adverse effects and interactions related to herbal and dietary supplements. Clin Toxicol. 2006 ; 44 : 605-610 https://doi.org/10.1080/15563650600795545
  3. Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, Anlong Xu, and James W. Paxton6Interactions of Herbs with Cytochrome P450. DRUG METABOLISM REVIEWS. 2003 ; 35(1) : 35-98 https://doi.org/10.1081/DMR-120018248
  4. 박수진, 권영규, 신재국. 국내 한약-양약 상호작용 연구논문 분석을 통한 상호작용 정보 현황파악 및 제공방안에 대한 연구. 동의생리병리학회지. 2010 ; 24(4) : 543-552
  5. Subhuti Dharmananda, THE INTERACTIONS OF HERBS AND DRUGS. file:///Volumes/GMC%20Herbology/other/herbdrug.htm
  6. 박영철, 독성학의 분자-생화학적 원리, 한국학술정보(주). 2010 ; ISBN: 978-89-268-1259-4
  7. Yao Chen, Zhen Kang, Jin Yanc, Guo-Ping Yangc, Zhi-Rong Tana, Gan Zhoua, Dong-Sheng Ouyanga, Liu Wei Di Huang Wan, a well-known traditional Chinese medicine, induces CYP1A2 while suppressing CYP2A6 and N-acetyltransferase 2 activities in man. Journal of Ethnopharmacology. 2010 ; 132 : 213-218 https://doi.org/10.1016/j.jep.2010.08.011
  8. Henderson, GL, Harkey, MR, Gershwin, ME, Hackman, RM, Stern, JS, Stresser, D M. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. Life Sci. 1999 ; 65 : PL209--PL214 https://doi.org/10.1016/S0024-3205(99)00407-5
  9. Henderson, MC, Miranda, CL, Stevens, JF, Deinzer, ML, Buhler, DR. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica. 2000 ; 30 : 235-251 https://doi.org/10.1080/004982500237631
  10. Paolini, M, Barillari, J, Broccoli, M, Pozzetti, L, Perocco, P, Cantelli-Forti, G. Effect of liquorice and glycyrrhizin on rat liver carcinogen metabolizing enzymes. Cancer Lett. 1999 ; 145 : 35-42 https://doi.org/10.1016/S0304-3835(99)00225-6
  11. Paolini, M., Pozzetti, L., Sapone, A., Cantelli-Forti, G. Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases. Life Sci. 1998 ; 62 : 571--582 https://doi.org/10.1016/S0024-3205(97)01154-5
  12. Jing-cheng Tang, Jin-nan Zhang, Yingting Wu and Zhao-xu Li. Effect of the Water Extract and Ethanol Extract from Traditional Chinese Medicines Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort. and Rheum palmatum L. on Rat Liver Cytochrome P450 Activity. Phytother. Res. 2006 ; 20 : 1046-1051 https://doi.org/10.1002/ptr.1974
  13. Guerraa, MC, E. Speronia, M. Broccolia, M. Canginia, P. Pasini, A. Minghetti, N. Crespi- Perellino, M. Mirasoli, G. Cantelli-Fortia, M. Paolini. Accelerated communication Comparison between Chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin : Antioxidant properties and effects on rat liver CYPcatalysed drug metabolism. Life Sciences. 2000 ; 67 : 2997-3006 https://doi.org/10.1016/S0024-3205(00)00885-7
  14. 정해광, 유효진, 장영수, 박성준, 문영희, 우은란. 생약추출물의 Cytochrome P450 약물대사 효소계 저해활성. 생약학회지. 2002 ; 33(1) : 35-41
  15. LIU Yong, YANG Ling Liu et al. Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics. SCIENCE B 2006 ; 7(2) : 99-106
  16. Richard T. Tovar and Renee M. Petzel. Herbal Toxicity Disease-a-Month, 2009 ; 55(10) : 592-641 https://doi.org/10.1016/j.disamonth.2009.05.001
  17. Janetzky, K, Morreale, A.P., 1997. Probable interaction between warfarin and ginseng. American Journal of Health-System Pharmacy. 54(6) : 692-693
  18. Heck, A. M., DeWitt, B. A., Lukes, A. L. (2000). Potential interactions between alternative therapies and warfarin. Am. J. Health-System Pharm. 57 : 1221-1227
  19. Yun, YP, Do, JH, Ko, SR, Ryu, SY, Kim, JH, Song, HC, Park, YD, Ahn, KS, Kim, SH. Effects of Korean red ginseng and its mixed prescription on the high molecular weight dextran-induced blood stasis in rats and human platelet aggregation. Journal of Ethnopharmacology. 2001 ; 77(2-3) : 259-264 https://doi.org/10.1016/S0378-8741(01)00303-8
  20. Chow L, Johnson M, Wells A. Effect of the traditional Chinese medicines Chan Su, Lu-Shen-Wan, Dan Shen, and Asian ginseng on serum digoxin measurement by Tina-quant (Roche) and Synchron LX system (Beckman) digoxin immunoassays. J Clin Lab Anal. 2003 ; 17 : 22-27 https://doi.org/10.1002/jcla.10064
  21. Shintani S, Murase H, Tsukagoshi H, et al. Glycyrrhizin (licorice) induced hypokalemic myopathy : Report of 2 cases and review of the literature. Eur Neurol. 1992 ; 32 : 44-51 https://doi.org/10.1159/000116786
  22. Theoharides TC. Sudden death of a healthy college student related to ephedrine toxicity from a Ma Huang containing drink. J Clin Psychopharmacol. 1997 ; 17 : 437-9 https://doi.org/10.1097/00004714-199710000-00025
  23. Neff GW, Reddy R, Durazo FA, et al. Letters to the editor : Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma Huang or usnic acid. J Hepatol. 2004 ; 41 : 1061-1067 https://doi.org/10.1016/j.jhep.2004.07.006
  24. Borum ML. Abstract : Fulminant exacerbation of autoimmune hepatitis following the use of Ma Huang. Am J Gastroenterol. 2000 ; 95 : 2566
  25. Dong quai. Natural Medicines Database. Therapeutic Research Faculty. Stockton, CA. Available at : http://www.naturaldatabase.com/(S(qku2mt55awj5j4iammokfc45))/home.aspx?cs&sND. Accessed January 2, 2008
  26. Monograph. Angelica sinensis (Dong quai). Altern Med Rev. 2004 ; 9 : 429-33
  27. Lau CBS, Ho TCY, Chan TWL, et al. Use of dong quai (Angelica sinensis) to treat peri- and postmenopausal symptoms in women with breast cancer : Is it appropriate? Menopause. 2005 ; 12 : 734-740 https://doi.org/10.1097/01.gme.0000184419.65943.01
  28. Garlic. Natural Medicines Database. Therapeutic Research Faculty. Stockton, CA. Available at : http://www.naturaldatabase.com/(S(qku2mt55awj5j4iammokfc45))/home.aspxcs&sND. Accessed January 11, 2008
  29. Wilkinson JM. Effect of ginger tea on the fetal development of Sprague-Daley rats. Reprod Toxicol. 2000 ; 14 : 507-12 https://doi.org/10.1016/S0890-6238(00)00106-4
  30. Shufeng Zhou, Hwee-Ling Koh, Yihuai Gao, Zhi-yuan Gong, Edmund Jon Deoon Lee Herbal bioactivation : The good, the bad and the ugly. Life Sciences. 2004 ; 74 : 935-968 https://doi.org/10.1016/j.lfs.2003.09.035
  31. Kwok Po Hau, RobertoGambari, Raymond SiuMingWong, Phyllanthus urinaria extract attenuates acetaminophen-induced hepatotoxicity : Involvement of cytochrome P450 CYP2E1. Desmond Phytomedicine. 2009 ; 16 : 751-760 https://doi.org/10.1016/j.phymed.2009.01.008