Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
권호 표지

Hypoglycemic and hypolipidemic effects of Allium victorialis leaf extract in high fat diet supplied mice

  • Ku, Sae-Kwang (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University) ;
  • Chung, In-Kwon (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Cheon, Woo-Hyun (Department of Neurology, College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Young-Joon (Department of Preventive Medicine, College of Oriental Medicine, Daegu Haany University)
  • Received : 2011.02.09
  • Accepted : 2011.04.26
  • Published : 2011.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

The hypoglycemic and hypolipidemic effects of Allium victorialis (AV) leaf methanol extract were evaluated in a high fat diet (HFD) supplied mice. Changes on the serum glucose, total cholesterol, triglyceride, low density lipoprotein and high density lipoprotein were examined. The effects were compared with those of a group given 250 mg/kg of metformin. After 91 days of a continuous HFD supply, the mice were showed marked hyperglycemia and hyperlipemia. However, these hyperglycemia and hyperlipemia induced by the HFD were inhibited by the AV extract treatment at the three different doses (62.5, 125 and 250 mg/kg). The results suggest that the AV methanol extract is beneficial for improving the diet-induced hyperlipidemia and hyperglycemia in humans.

Keywords

References

  1. James PT, Leach R, Kalamara E, Shayeghi M. The worldwide obesity epidemic. Obes Res. 2001 ; 9 : 228S-233S. https://doi.org/10.1038/oby.2001.123
  2. Surwit RS, Kuhn CM, Cochrane C, Mc-Cubbin JA, Feinglos MN. Diet-induced type II diabetes in C57BL/6J mice. Diabetes 1988 ; 37 : 1163-1167. https://doi.org/10.2337/diabetes.37.9.1163
  3. Thupari JN, Kim EK, Moran TH, Ronnett GV, Kuhajda FP. Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am. J. Physiol. Endocrinol Metab. 2004 ; 287 : E97-104. https://doi.org/10.1152/ajpendo.00261.2003
  4. Yun SN, Moon SJ, Ko SK, Im BO, Chung SH. Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in ICR mice. Arch Pharm Res. 2004 ; 27 : 790-796. https://doi.org/10.1007/BF02980150
  5. Park SH, Ko SK, Chung SH. Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice. J Ethnopharmacol. 2005 ; 102 : 326-335. https://doi.org/10.1016/j.jep.2005.06.041
  6. Seufert J, Lubben G, Dietrich K, Bates PC. A comparison of the effects of thiazolidinediones and metformin on metabolic control in patients with type 2 diabetes mellitus. Clin Ther. 2004 ; 26 : 805-818. https://doi.org/10.1016/S0149-2918(04)90125-7
  7. Inzucchi SE. Oral antihyperglycemic therapy for type 2 diabetes : scientific review. JAMA 2002 ; 287 : 360-372. https://doi.org/10.1001/jama.287.3.360
  8. Kim TG, Kim SH, Kang SY, Jung KK, Choi DH, Park YB, Ryu JH, Han HM. Antiatherogenic effect of the extract of Allium victorialis on the experimental atherosclerosis in the rabbit and transgenic mouse. Korean J Pharmacog. 2000 ; 31 : 149-156.
  9. Lee KT, Choi JH, Kim DH, Son KH, Kim WB, Kwon SH, Park HJ. Constituents and the antitumor principle of Allium victorialis var. platyphyllum. Arch Pharm Res. 2001 ; 24 : 44-50. https://doi.org/10.1007/BF02976492
  10. Shirataki Y, Motohashi N, Tani S, Sunaga K, Sakagami H, Satoh K, Nakashima H, Kanamoto T, Wolfard K, Molnar J. Antioxidative activity of Allium victorialis L. extracts. Anticancer Res. 2001 ; 21 : 3331-3339.
  11. Ahn YM, Lim SJ, Han HK, Choi SS. Effects of Allium vegetable intake on levels of plasma glucose, lipid and minerals in streptozotocin induced diabetic rats. Korean J Nutrition 2006 ; 39 : 433-443.
  12. Ku SK, Kim JW. Hepatoprotective and nephroprotective effects of Allium victorialis leaf extracts on the high fat diet supplied mice. J Vet Clin 2010 ; 27 : 225-231.
  13. Sone H, Suzuki H, Takahashi A, Yamada N. Disease model : hyperinsulinemia and insulin resistance. Part A-targeted disruption of insulin signaling or glucose transport. Trends Mol Med. 2001 ; 7 : 320-322. https://doi.org/10.1016/S1471-4914(01)02041-X
  14. Sathishsekar D, Subramanian S. Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats. Biol Pharm Bull. 2005 ; 28 : 978-983. https://doi.org/10.1248/bpb.28.978
  15. Milionis HJ, Kakafika AI, Tsouli SG, Athyros VG, Bairaktari ET, Seferiadis KI, Elisaf MS. Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia. Am Heart J. 2004 ; 148 : 635-640. https://doi.org/10.1016/j.ahj.2004.04.005
  16. Forrester JS, Makkar R, Shah PK. Increasing high-density lipoprotein cholesterol in dyslipidemia by cholesteryl ester transfer protein inhibition : an update for clinicians. Circulation 2005 ; 111 : 1847-1854. https://doi.org/10.1161/01.CIR.0000160860.36911.BD
  17. Kamada T, Hata J, Kusunoki H, Ito M, Tanaka S, Kawamura Y, Chayama K, Haruma K. Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients. Dig Liver Dis. 2005 ; 37 : 39-43. https://doi.org/10.1016/j.dld.2004.07.017
  18. Cheng JW. Rosuvastatin in the management of hyperlipidemia. Clin Ther. 2004 ; 26 : 1368-1387. https://doi.org/10.1016/j.clinthera.2004.09.005
  19. Garg MC, Singh KP, Bansal DD. Effect of vitamin C supplementation on oxidative stress in experimental diabetes. Indian J Exp Biol. 1997 ; 35 : 264-266.
  20. Collier A, Wilson R, Bradley H, Thomson JA. Small M. Free radical activity in type 2 diabetes. Diabet Med. 1990 ; 7 : 27-30. https://doi.org/10.1111/j.1464-5491.1990.tb01302.x
  21. Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 1996 ; 19 : 257-267. https://doi.org/10.2337/diacare.19.3.257
  22. Hong JH, Lee IS. Effects of Artemisia capillaris ethyl acetate fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice. Chem Biol Interact. 2009 ; 179 : 88-93. https://doi.org/10.1016/j.cbi.2008.12.002