대한본초학회지 (The Korea Journal of Herbology)

  • 제26권1호
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  • Pages.59-63
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  • 2011
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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황기(黃芪)의 elastase 활성과 DPPH, NO 소거능에 미치는 영향

Effects of Astragali Radix Extracts on the Elastase Activity and DPPH and NO Scavenging Activities

  • 투고 : 2011.02.15
  • 심사 : 2011.03.10
  • 발행 : 2011.03.30
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초록

Objectives : Elastic fibers are found in the skin, lungs, arteries, veins and other structures. The defects of elastic matrix aggravate hypertension which is associated with alteration in the great arteries, arteries, and arterioles. The elastase inhibitors were undergoing in clinical studies about emphysema and pulmonary hypertension. This study was designed to investigate the effect of Astragali Radix extracts (AR) on elastase activity and anti-oxidative effects. Methods : The elastase inhibitory activity and DPPH (1,1-diphenyl-2-picrylhydrazyl) and NO free radical scavenging activities of AR were measured. Results : The elastase activity was significantly inhibited by AR. The significant DPPH and NO free radical scavenging activities were observed in AR as well. Conclusion : AR showed the anti-elastase effects and anti-oxidative activities in vitro. These results suggest that AR may be a possible drug for the treatment of pulmonary emphysema and pulmonary hypertension.

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참고문헌

  1. Kim IR, Kim HC, Kuk YB, Park SJ, Park YK, Park JH, Seo BI, Seo YB, Song HJ, Shin MK, Lee YJ, Lee YC, Lee JH, Leem KH, Cho SI, Chung JK, Joo YS, Choi HY. Boncho-Hak. Seoul : Young-Lim Press. 2007 : 576-8.
  2. Chen JL, Chen TT. Chinese Medical Herbology and Pharmacology. CA : Art of Medicine Press. 2004 : 847-53.
  3. Bieth JG. The elastases. J Soc Biol. 2001 ; 195(2) : 173-9. https://doi.org/10.1051/jbio/2001195020173
  4. Loukanov T, Geiger R, Agrawal R. Animal models related to congenital heart disease and clinical research in pulmonary hypertension. Cardiology. 2010 ; 116(1) : 18-25. https://doi.org/10.1159/000313865
  5. Dewachter L, Dewachter C, Naeije R. New therapies for pulmonary arterial hypertension : an update on current bench to bedside translation. Expert Opin Investig Drugs. 2010 ; 19(4) : 469-88. https://doi.org/10.1517/13543781003727099
  6. Stenmark KR, Rabinovitch M. Emerging therapies for the treatment of pulmonary hypertension. Pediatr Crit Care Med. 2010 ; 11(2 Suppl) : S85-90. https://doi.org/10.1097/PCC.0b013e3181c76db3
  7. Huang JB, Liu YL, Sun PW, Lv XD, Bo K, Fan XM. Novel strategy for treatment of pulmonary arterial hypertension : enhancement of apoptosis. Lung. 2010 ; 188(3) : 179-89. https://doi.org/10.1007/s00408-010-9233-8
  8. Fischer B, Voynow J. Neutrophil elastase induces MUC5AC messenger RNA expression by an oxidant-dependent mechanism. Chest. 2000 ; 117(5 Suppl 1) : 317S-20S. https://doi.org/10.1378/chest.117.5_suppl_1.317S
  9. Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am J Respir Cell Mol Biol. 2002 ; 26(4) : 447-52. https://doi.org/10.1165/ajrcmb.26.4.4473
  10. Kawai M, Harada N, Takeyama H, Okajima K. Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats. Transl Res. 2010 ; 155(6) : 294-304. https://doi.org/10.1016/j.trsl.2010.02.003
  11. Kraunsoe JA, Claridge TDW, Lowe, G. Inhibition of human leukocyte and porcine pancreatic elastase by homologues of bovine pancreatic trypsin inhibitor. Biochemistry. 1996 ; 35 : 9090-6. https://doi.org/10.1021/bi953013b
  12. Kim YH, Chung CB, Kim JG, Ko KI, Park SH, Kim JH, Eom SY, Kim YS, Hwang YI, Kim KH. Anti-Wrinkle Activity of Ziyuglycoside I Isolated from a Sanguisorba officinalis Root Extract and Its Application as a Cosmeceutical Ingredient. Biosci Biotechnol Biochem. 2008 ; 72(2) : 303-11. https://doi.org/10.1271/bbb.70268
  13. Shimada K, Fugikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthan on the autoxiation of soy gean oil in cyclodextrin emulsion. J Agric Food Chem. 1992 ; 40 : 945-8. https://doi.org/10.1021/jf00018a005
  14. Kato H, Lee IE, Chuyen NV, Kim SB, Hayase F. Inhibition of nitrosamine formation by nondialyzable melanoidins. Agric Biol Chem. 1987 ; 51(5) : 1333-8. https://doi.org/10.1271/bbb1961.51.1333
  15. Yang ZY, Guon GX, Lin ZF. Elastolytic activity from Flavobacterium odoratum. Microbial screening and cultivation, enzyme production and purification. Process Biochem. 1994 ; 29 : 427-36. https://doi.org/10.1016/0032-9592(94)85010-0
  16. Wiltried M, Klaus N, Lin ZF. Elastic fibre arrangement in the skin of the pig. Arch Derm Res. 1994 ; 270 : 390-401.
  17. Wiedow O, Schroder JM, Christophers E. An elastase-specific inhibitor of human skin. J Biol Chem. 1990 ; 265 : 14791-5.
  18. Reboud-Ravaux M. Elastase inhibitors. J Soc Biol. 2001 ; 195(2) : 143-50. https://doi.org/10.1051/jbio/2001195020143
  19. Boyer L, Plantier L, Dagouassat M, Lanone S, Goven D, Caramelle P, Berrehar F, Kerbrat S, Dinh-Xuan AT, Crestani B, Le Gouvello S, Boczkowski J. Role of nitric oxide synthases in elastase-induced emphysema. Lab Invest. 2011 ; 91(3) : 353-62. https://doi.org/10.1038/labinvest.2010.169

피인용 문헌

  1. 황기분말 첨가 설기떡의 품질특성 vol.29, pp.3, 2011, https://doi.org/10.9724/kfcs.2013.29.3.233
  2. 재배년수에 따른 인삼의 생육특성, 생리활성, 성분의 변화 vol.27, pp.6, 2019, https://doi.org/10.7783/kjmcs.2019.27.6.383