Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Anti-inflammatory Effect of Fermented Red Ginseng Via Regulation of NF-${\kappa}$B Signal Transduction

발효 홍삼의 NF-${\kappa}$B 신호전달 조절을 통한 항염증 효과

  • 황성인 (부산대학교 한의학전문대학원) ;
  • 주현정 (부산대학교 한의학전문대학원) ;
  • 김효동 (부산대학교 한의학전문대학원) ;
  • 곽태원 (부산대학교 한의학전문대학원) ;
  • 유병홍 ((주)바이오포트코리아) ;
  • 김성구 ((주)바이오포트코리아) ;
  • 이철원 (부산대학교 해양생물기술연구소) ;
  • 황태호 (부산대학교 한의학전문대학원) ;
  • 안원근 (부산대학교 한의학전문대학원)
  • Received : 2011.05.27
  • Accepted : 2011.06.13
  • Published : 2011.06.25
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Abstract

Recently, Korean ginseng, as immuno-activator, was actively investigated on its effect and mechanism. But purified fermented red ginseng (PFRG) has not been researched enough compared to red ginseng (RG, steamed and dried root of Panax ginseng C. A. Meyer, family Araliaceae) and fermented red ginseng (FRG, fermented red ginseng by Lactobacillus brevis 13094). In this study, we examined RG, FRG and PFRG to compare their anti-inflammatory effect by LPS. According to the result, RAW 264.7 cells survival rates did not largely change by RG and FRG. Only PFRG expressed weak toxicity at 10 ug/ml. The expression of iNOS and production of Nitric Oxide (NO) decreased depending on the concentration of RG, FRG and PFRG. And the expression of COX-2 also decreased. We tried western blotting for detecting that the expression of iNOS, COX-2 was caused by NF-${\kappa}B$. The result supported that the inhibition of NF-${\kappa}B$ by RG, FRG and PFRG suppressed the expression of iNOS, COX-2 and affected the production of TNF-${\alpha}$. While the anti-inflammatory effect was confirmed from all three types of red ginseng (RG, FRG, PFRG), the effect of PFRG was superior to others. Further research is required on other effects of PFRG.

Keywords

References

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