Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Sulfuretin Inhibits Ultraviolet B-induced MMP Expression in Human Dermal Fibroblasts

  • So, Hong-Seob (Department of Microbiology, Wonkwang University School of Medicine) ;
  • Kim, Seung-Hoon (Department of Pharmacology, Seonam University Medical School) ;
  • Lee, Young-Rae (Department of Biochemistry, Chonbuk National University Medical School)
  • Received : 2011.05.13
  • Accepted : 2011.06.15
  • Published : 2011.06.25
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Abstract

Sulfuretin is one of the main flavonoids produced by Rhusverniciflua. Sulfuretin has been shown to exhibit many pharmacological activities including anti-oxidant, anti-obesity, anti-inflammatory and anti-mutagenic activities. However, the anti-skin photoaging effects of sulfuretin has not yet been reported. In the present study, we investigated the inhibitory effect of sulfuretin on the expression levels of MMP-1 and -3 in the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed sulfuretin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB-induced MAPK/NF-${\kappa}B$/p50 activation and MMP expression were completely blocked by pretreatment of sulfuretin. Taken together, sulfuretin could prevent UVB-induced MMP expressions through inhibition of MAPK/NF-${\kappa}B$/p50 activation.

Keywords

References

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