Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Curcumin on UVB-irradiated Inflammation in HaCaT Keratinocyte Cells

울금의 Curcumin 성분이 자외선 B 조사에 의해 발생한 염증에 미치는 영향

  • Lee, Ju-Yeon (Graduate School of Public Health, Daegu Haany University) ;
  • Lee, Eun-Ju (Institute for Nursing Science, Keimyung University) ;
  • Lee, Young-Sun (Department of Bio-Applied Science, Sung Duk C. University) ;
  • Yoo, Wang-Keun (Graduate School of Public Health, Daegu Haany University)
  • 이주연 (대구한의대학교 보건대학원) ;
  • 이은주 (계명대학교 간호대학 간호과학연구소) ;
  • 이영선 (성덕대학 바이오실용과학계열) ;
  • 유왕근 (대구한의대학교 보건대학원)
  • Received : 2011.09.09
  • Accepted : 2011.12.05
  • Published : 2011.12.25
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Abstract

Curcumin is a natural phytochemical present in turmeric, the ground powder of the rhizomes of Curcuma longa. Curcumin has been described as having antioxidant, anti-inflammatory, and anti-carcinogenic properties. However, it is still largely unknown whether curcumin inhibits the UVB-induced inflammatory reaction in HaCaT keratinocyte cell lines. In this study, to confirm the photoprotection properties of curcumin, HaCaT keratinocyte cells were irradiated by UVB, and then treated with curcumin. UVB irradiation induced the increased expressions of IL-$1{\beta}$, TNF-${\alpha}$, IL-6, IL-8, and COX-2 in HaCaT cells. These increased expressions of cytokines (IL-$1{\beta}$, TNF-${\alpha}$, IL-6, IL-8, and COX-2) were down-regulated by curcumin treatment in UVB-irradiated HaCaT cells. In addition skin of hairless mice were damaged by UVB irradiation, which were evidenced by atrophy of epidermis and decrease of collagen in dermis. However, these damages were protected partially by co-treatment of curcumin. Taken together, this data indicate that curcumin may be a promising photoprotection agent, when used in massage pack or sunscreen product, to reduce cell death in UV-damaged skin.

Keywords

References

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