한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제40권7호
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  • Pages.956-961
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  • 2011
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  • 1226-3311(pISSN)
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  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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우주식품으로 개발한 30 kGy 감마선 조사된 건조우주비빔밥의 3개월 독성평가

Toxicity Evaluation of 30 kGy Irradiated Dried Space Bibimbap for Three Months

  • 박재남 (한국원자력연구원 정읍방사선과학연구소 방사선식품생명공학팀) ;
  • 김진경 (대구가톨릭대학교 의생명과학과) ;
  • 최단비 (한림대학교 식품영양학과.한국영양연구소) ;
  • 김재훈 (한국원자력연구원 정읍방사선과학연구소 방사선식품생명공학팀) ;
  • 송범석 (한국원자력연구원 정읍방사선과학연구소 방사선식품생명공학팀) ;
  • 이주운 (한국원자력연구원 정읍방사선과학연구소 방사선식품생명공학팀) ;
  • 강일준 (한림대학교 식품영양학과.한국영양연구소)
  • Park, Jae-Nam (Team for Radiation Food Science and Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kim, Jin-Kyung (Dept. of Medical Life Science, Catholic University of Daegu) ;
  • Choi, Dan-Bi (Dept. of Food Science and Nutrition & The Korean Institute of Nutrition, Hallym University) ;
  • Kim, Jae-Hun (Team for Radiation Food Science and Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Song, Beom-Seok (Team for Radiation Food Science and Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Lee, Ju-Woon (Team for Radiation Food Science and Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kang, Il-Jun (Dept. of Food Science and Nutrition & The Korean Institute of Nutrition, Hallym University)
  • 투고 : 2010.11.18
  • 심사 : 2011.01.18
  • 발행 : 2011.07.31
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초록

본 연구는 건조우주비빔밥의 안전성을 확보하기 위해서 고선량(30 kGy) 조사된 건조우주비빔밥을 ICR 마우스에 3개월간 섭취시킨 다음 독성평가를 수행하였다. 비조사 시료 및 30 kGy 조사 비빔밥을 암수 마우스에 투여를 한 결과 시험기간 동안 시험물질에 의한 임상증상이나 폐사 동물은 나타나지 않았으며, 체중 변화, 사료섭취량 및 주요 장기 무게도 대조군에 비해 차이를 보이지 않았다. 혈액학적 검사 및 혈청학적 검사 모두 정상적인 수치를 나타냈다. 병리조직학적 검사 역시 간 및 신장 모두 정상적인 구조를 유지하고 있었으며 염증, 괴사 등의 유의할 만한 병적 변화도 관찰되지 않았다. 따라서 30 kGy로 감마선 조사된 건조우주비빔밥은 암수 마우스에 3개월간 섭취시켜도 본 시험조건에서는 독성이 없는 것으로 판명되었다.

This study was conducted to evaluate the possible subacute toxicity of gamma-irradiated dried bibimbap. The dried bibimbap was irradiated at the dose of 30 kGy at room temperature. For the animal study, the male and female ICR mice (8 mice per group) had the diet with AIN39G as control and dried bibimbap 30 kGy irradiated and non-irradiated for three months. During the experimental period, the group with 30 kGy irradiated bibimbap did not show any changes in appearance, behavior, mortality, body weight, organ weight, and food consumption compared to the control. Also, all of the biochemical parameters were observed in the normal ranges. In histopathological examination including hematological and serum biochemical analyses, there were no significant differences among the control and 30 kGy irradiated dried bibimbap groups. These results indicate that irradiation of bibimbap up to 30 kGy did not cause any toxic effects and could be applied for the development of safe ready-to-cook food.

키워드

참고문헌

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피인용 문헌

  1. Safety Evaluation of 30 kGy Irradiated Chocolate Ice Cream vol.42, pp.6, 2013, https://doi.org/10.3746/jkfn.2013.42.6.898
  2. Long term food stability for extended space missions: a review vol.32, pp.None, 2011, https://doi.org/10.1016/j.lssr.2021.12.003