Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Development of Correction Technologies for Quantification of Photon Measurement in Bio-Luminescence Image

생체발광영상에서 포톤 검출 정량화를 위한 보정기법의 개발

  • Tak, Yoon-Oh (Department of Nuclear Medicine, Chonnam National University Hwasun Hospital) ;
  • Kim, Hyeon-Sik (Department of Nuclear Medicine, Chonnam National University Hwasun Hospital) ;
  • Park, Hyeong-Ju (Department of Nuclear Medicine, Chonnam National University Hwasun Hospital) ;
  • Choi, Heung-Kook (Department of Computer Science, Inje University) ;
  • Choi, Eun-Seo (Department of Physics, Chosun University) ;
  • Hann, S.-Wook (Korea Photonics Technology Institute) ;
  • Lee, Byeong-Il (Department of Nuclear Medicine, Chonnam National University Hwasun Hospital)
  • Received : 2010.11.02
  • Accepted : 2011.03.11
  • Published : 2011.04.30
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Abstract

Bioluminescence imaging (BLI) is the most sensitive animal imaging technique for molecular imaging research. Generally, highly sensitive CCD is used to detect an optical probe introduced in a living mouse. However, in many cases, the light signal emitted from a probe is too small to detect because it is scattered and attenuated by the tissue prior to being detected. The problem is that scattering and attenuation not only inhibit accurate measurement but also make image quality down. Thus we introduced a new method to reduce noise by using property of CCD and method to improve image quality of bioluminescence image by using two steps Gaussian blurring.

Keywords

Acknowledgement

Supported by : 한국연구재단, 광주과학기술원

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