Beneficial Effect of a Collagen Peptide Supplement on the Epidermal Skin Barrier

콜라겐 펩타이드의 피부 장벽 보호 효과

  • 김정기 ((주)아모레퍼시픽 기술연구원) ;
  • 이지해 ((주)아모레퍼시픽 기술연구원) ;
  • 배일홍 ((주)아모레퍼시픽 기술연구원) ;
  • 서대방 ((주)아모레퍼시픽 기술연구원) ;
  • 이상준 ((주)아모레퍼시픽 기술연구원)
  • Received : 2010.12.31
  • Accepted : 2011.05.18
  • Published : 2011.08.31


Recent studies have revealed that collagen peptide (CP) plays a protective role in skin by improving the activity of antioxidants and acts as an inducer of skin regeneration by positive feedback. In this study, we focused on the beneficial effect of reinforcing the CP skin barrier. To evaluate the skin barrier, hairless mice were exposed to UVB irradiation and acetone-treatment, with or without oral administration of CP. The effects on skin appearance, trans-epidermal water loss, epidermal thickness, and cytokine content were measured using bioengineering and histochemical methods. In the CP treated group, the skin had better appearance and less damage than that of the control. Furthermore, in HaCaT cells, the amount of serinepalmytoyl transferase (SPT) mRNA increased by about 1.6-fold after treatment (CP, 100 mg/L), reflecting that CP can induce SPT expression and reinforce the recovery of skin barrier function. These results suggest that CP is not only an anti-wrinkling agent but also a potent candidate as an epidermal moisturizer.


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