Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Protective Effects of Food Including Hovenia dulcis on Acute Alcohol Intoxication

급성 알코올 중독에서 헛개나무 추출물을 포함한 식품 조성물의 보호 효과

  • Received : 2011.06.17
  • Accepted : 2011.07.26
  • Published : 2011.08.31
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Abstract

Over-consumption of alcohol leads to many side-effects such as malnutrition, liver disease, and neuronal disorders and many investigators have tired to identify methods for preventing the side-effects of drinking. In this study, we demonstrated the protective effect of a new food component, SAC-1, containing Hovenia dulcis Thumb and Lonicera caerulea Thumb extract against the side-effects of drinking. We observed that blood alcohol concentration, glutamic oxaloacetate transaminase, lipid peroxidation, and total glutathione level decreased significantly in plasma and liver of mice fed the SAC-1 extract before alcohol intoxication. In particular, SAC-1 had more of a protective effect than that of Hovenia dulcis Thumb extract alone. These results suggest that SAC-1 should further be developed to treat alcohol detoxification and stimulate antioxidative potentials.

본 연구는 기존에 알코올 해독 기능이 우수한 것으로 알려진 헛개나무 열매 추출물과 헛개나무 열매 추출물을 주성분으로 하여 매실 및 댕댕이나무 열매 추출물이 혼합되어진 새로운 식품 조성물의 항알코올 기능에 대한 효능을 비교 분석함으로써 새로운 알코올 독성 경감 소재를 개발하고자 하였다. 새로운 식품 조성물인 SAC-1을 흰쥐에게 투여한 후 알코올을 섭취시켰을 때 혈중 알코올 농노의 저하가 헛개나무 추출물에 비하여 매우 우수한 효능이 있는 것으로 나타났으며, 간손상의 지표인 GOT, GPT에 있어서 대조군에 비하여 낮은 값을 나타내어 알코올에 의한 간손상을 경감시킬 수 있는 것으로 생각된다. 또한, 조직에서 산화적 손상으로 효능을 살펴본 결과는 지질과산화물의 생성을 혈장과 간 조직에서 모두 억제하는 것으로 나타났으며, total glutathione의 감소를 억제하는 것으로 나타나 SAC-1은 알코올성 조직 손상에서 충분한 보호 작용을 나타낼 수 있었던 것으로 생각된다. 특히 SAC-1은 헛개나무 열매 추출물 단독 사용에 비해서 더 높은 활성을 나타낸 것으로 나타났으며, 이것은 SAC-1이 알코올 해독에 좋은 천연 성분을 함유하고 있는 결과로 추측된다. 이상의 결과에서 SAC-1은 알코올로 인해 유도되어지는 조직 손상 및 숙취 증상으로부터 조직을 보호할 수 있는 능력이 있는 것으로 생각된다.

Keywords

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