대한수의학회지 (Korean Journal of Veterinary Research)

  • 제51권3호
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  • Pages.177-183
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  • 2011
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  • 2466-1384(pISSN)
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  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지
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Protective effect of the methanol extract of Polyopes lancifolia (Harvey) kawaguchi et wang against ionizing radiation-induced mouse gastrointestinal injury

  • Jeong, Jinwoo (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Yang, Wonjun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Ahn, Meejung (Applied Radiological Science Research Institute, Jeju National University) ;
  • Kim, Ki Cheon (Applied Radiological Science Research Institute, Jeju National University) ;
  • Hyun, Jin Won (Applied Radiological Science Research Institute, Jeju National University) ;
  • Kim, Sung-Ho (Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University) ;
  • Moon, Changjong (Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University) ;
  • Shin, Taekyun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • 투고 : 2011.06.02
  • 심사 : 2011.07.21
  • 발행 : 2011.09.30
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초록

The radioprotective efficacy of a methanol extract of the red algae Polyopes lancifolia (Harvey) kawaguchi et wang (mPL) was evaluated in mice subjected to total-body gamma irradiation. mPL protection against radiation-induced oxidative stress was examined by histological evaluation of intestinal crypt-cell survival and liver activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). mPL (100 mg/kg body weight) administered intraperitoneally at 24 h and 1 h prior to irradiation protected jejunal crypt cells from radiation-induced apoptosis (p < 0.01). The pretreatment of mPL attenuated a radiation-induced decrease in villous height (p < 0.05), and improved jejunal crypt survival (p < 0.05). The dose reduction factor was 1.14 at 3.5 days after irradiation. Treatment with mPL prior to irradiation resulted in significantly higher (p < 0.01) levels of SOD and CAT activities, compared to those levels of irradiated control mice with vehicle treatment. These results suggest that mPL is a useful radioprotective agent capable of defending intestinal progenitor cells against total-body irradiation, at least in part through mPL antioxidative activity.

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피인용 문헌

  1. Aquatic Phlorotannins and Human Health: Bioavailability, Toxicity, and Future Prospects vol.16, pp.12, 2011, https://doi.org/10.1177/1934578x211056144