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Efficacy test of sustained-release somatotropin by implantation in steer, cow and barrow

비육우, 젖소 및 비육돈에서 이식형 소마토트로핀 지속성 제형의 유효성 시험 연구

  • Accepted : 2011.03.14
  • Published : 2011.03.30

Abstract

Sixteen steers were used to investigate the efficacy of the sustained-release implant of bovine somatotropin (bST) in improving growth and feed:gain ratio during 12 weeks. Administration of the 400 mg bST implant resulted in a 16.1% increase in growth rate, and this increase was significant (p<.05). The use of the sustained-release implant did not alter (p>.05) feed intake and feed:gain ratio. Thirty-four cows were used to investigate the efficacy of the sustained-release implant of bST in milk production during 4 weeks. Administration of the 200 mg bST implant resulted in an 8.7% increase in milk production, and this increase was significant (p<.05). Twenty-four barrows were used to investigate the efficacy of the sustained-release implant of porcine somatotropin (pST) in improving growth, feed:gain ratio and backfat thickness during 6 weeks. Administration of the 120 mg pST implant resulted in a 11.4% increase in feed:gain ratio and a 60% decrease in backfat thickness, and these results were significant (p<.05). But the use of the sustained-release implant did not alter (p>.05) growth rate and feed intake.

Keywords

References

  1. 김남중. Somatotropin 이식 제형 개발과 지속성 방출 효과. 대한수의학회지 2008, 48, 27-32.
  2. 김남중. 비육우에서 이식형 bovine somatotropin 지속성 제형의 blood profile test. 대한수의학회지 2009, 49, 9-15.
  3. Azain MJ, Roberts TJ, Martin RJ, Kasser TR. Comparison of daily versus continuous administration of somatotropin on growth rate, feed intake, and body composition in intact female rats. J Anim Sci 1995, 73, 1019-1029.
  4. Bass JJ, Hodgkinson SC, Breier BH, Carter WD, Gluckman PD. Effects of bovine somatotrophin on insulin-like growth factor-I, insulin, growth and carcass composition of lambs. Livest Prod Sci 1992, 31, 321-334. https://doi.org/10.1016/0301-6226(92)90078-I
  5. Bauman DE. Bovine somatotropin and lactation: from basic science to commercial application. Domest Anim Endocrinol 1999, 17, 101-116. https://doi.org/10.1016/S0739-7240(99)00028-4
  6. Beermann DH, Fishell VK, Roneker K, Boyd RD, Armbruster G, Souza L. Dose-response relationships between porcine somatotropin, muscle composition, muscle fiber characteristics and pork quality. J Anim Sci 1990, 68, 2690-2697.
  7. Biesma B, de Vries EG, Willemse PH, Sluiter WJ, Postmus PE, Limburg PC, Stern AC, Vellenga E. Efficacy and tolerability of recombinant human granulocyte-macrophage colony-stimulating factor in patients with chemotherapy-related leukopenia and fever. Eur J Cancer 1990, 26, 932-936. https://doi.org/10.1016/0277-5379(90)90613-X
  8. Buskirk DD, Faulkner DB, Hurley WL, Kesler DJ, Ireland FA, Nash TG, Castree JC, Vicini JL. Growth, reproductive performance, mammary development, and milk production of beef heifers as influenced by prepubertal dietary energy and administration of bovine somatotropin. J Anim Sci 1996, 74, 2649-2662.
  9. Christensen H, Oxlund H, Laurberg S. Growth hormone increases the bursting strength of colonic anastomoses. An experimental study in the rat. Int J Colorectal Dis 1990, 5, 130-134. https://doi.org/10.1007/BF00300401
  10. Collier RJ, Byatt JC, Denham SC, Eppard PJ, Fabellar AC, Hintz RL, McGrath MF, McLaughlin CL, Shearer JK, Veenhuizen JJ, Vicini JL. Effects of sustained release bovine somatotropin (sometribove) on animal health in commercial dairy herds. J Dairy Sci 2001, 84, 1098-1108. https://doi.org/10.3168/jds.S0022-0302(01)74570-5
  11. Cravener TL, Vasilatos-Younken R, Wellenreiter RH. Effect of subcutaneous infusion of pituitaryderived chicken growth hormone on growth performance of broiler pullets. Poult Sci 1989, 68, 1133-1140. https://doi.org/10.3382/ps.0681133
  12. Crooker BA, McGuire MA, Cohick WS, Harkins M, Bauman DE, Sejrsen K. Effect of dose of bovine somatotropin on nutrient utilization in growing dairy heifers. J Nut 1990, 120, 1256-1263.
  13. Dahl GE, Chapin LT, Allen MS, Moseley WM, Tucker HA. Comparison of somatotropin and growth hormone-releasing factor on milk yield, serum hormones, and energy status. J Dairy Sci 1991, 74, 3421-3428. https://doi.org/10.3168/jds.S0022-0302(91)78532-9
  14. Early RJ, McBride BW, Ball RO. Growth and metabolism in somatotropin-treated steers: I. Growth, serum chemistry and carcass weights. J Anim Sci 1990, 68, 4134-4143.
  15. Enomoto M, Nishiguchi S, Fukuda K, Kuroki T, Tanaka M, Otani S, Ogami M, Monna T. Characteristics of patients with hepatitis C virus with and without GB virus C/hepatitis G virus co-infection and efficacy of interferon alfa. Hepatology 1998, 27, 1388-1393. https://doi.org/10.1002/hep.510270528
  16. Enright WJ, Quirke JF, Gluckman PD, Breier BH, Kennedy LG, Hart LC, Roche JF, Coert A, Allen P. Effects of long-term administration of pituitaryderived bovine growth hormone and estradiol on growth in steers. J Anim Sci 1990, 68, 2345-2356.
  17. Erdman RA, Sharma BK, Shaver RD, Cleale RM. Dose response to recombinant bovine somatotropin from weeks 15 to 44 postpartum in lactating dairy cows. J Dairy Sci 1990, 73, 2907-2915. https://doi.org/10.3168/jds.S0022-0302(90)78978-3
  18. Garavelli PL. Efficacy of granulocyte colonystimulating factor (G-CSF) on neutropenia in zidovudinetreated patients with AIDS and ARC: a preliminary report. Haematologica 1992, 77, 293-294.
  19. Ghosh P. The role of hyaluronic acid (hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluid. Clin Exp Rheumatol 1994, 12, 75-82.
  20. Goh KT, Oon CJ, Heng BH, Lim GK. Long-term immunogenicity and efficacy of a reduced dose of plasma-based hepatitis B vaccine in young adults. Bull World Health Organ 1995, 73, 523-527.
  21. Groenewegen PP, McBride BW, Burton JH, Elsasser TH. Effect of bovine somatotropin on the growth rate, hormone profiles and carcass composition of Holstein bull calves. Domest Anim Endocrinol 1990, 7, 43-54. https://doi.org/10.1016/0739-7240(90)90053-3
  22. Harn NR, Jeng YN, Kostelc JG, Middaugh CR. Spectroscopic analysis of highly concentrated suspensions of bovine somatotropin in sesame oil. J Pharm Sci 2005, 94, 2487-2495. https://doi.org/10.1002/jps.20464
  23. Harrell RJ, Thomas MJ, Boyd RD, Czerwinski SM, Steele NC, Bauman DE. Effect of porcine somatotropin administration in young pigs during the growth phase from 10 to 25 kilograms. J Anim Sci 1997, 75, 3152-3160.
  24. Herndon DN, Barrow RE, Kunkel KR, Broemeling L, Rutan RL. Effects of recombinant human growth hormone on donor-site healing in severely burned children. Ann Surg 1990, 212, 424-431. https://doi.org/10.1097/00000658-199010000-00005
  25. Holzer Z, Aharoni Y, Brosh A, Orlov A, Veenhuizen JJ, Kasser TR. The effects of long-term administration of recombinant bovine somatotropin (Posilac) and Synovex on performance, plasma hormone and amino acid concentration, and muscle and subcutaneous fat fatty acid composition in Holstein-Friesian bull calves. J Anim Sci 1999, 77, 1422-1430.
  26. Jenny BF, Grimes LW, Pardue FE, Rock DW, Patterson DL. Lactational response of Jersey cows to bovine somatotropin administered daily or in a sustained-release formulation. J Dairy Sci 1992, 75, 3402-3407. https://doi.org/10.3168/jds.S0022-0302(92)78116-8
  27. Jordan DC, Aguilar AA, Olson JD, Bailey C, Hartnell GF, Madsen KS. Effects of recombinant methionyl bovine somatotropin (Sometribove) in high producing cows milked three times daily. J Dairy Sci 1991, 74, 220-226. https://doi.org/10.3168/jds.S0022-0302(91)78163-0
  28. Klindt J, Buonomo FC, Yen JT, Pond WG, Mersmann HJ. Administration of porcine somatotropin by daily injection: growth and endocrine responses in genetically lean and obese barrows and gilts. J Anim Sci 1995, 73, 3294-3303.
  29. McLaughlin CL, Hedrick HB, Veenhuizen JJ, Hintz RL, Munyakazi L, Kasser TR, Baile CA. Performance, clinical chemistry, and carcass responses of finishing lambs to formulated sometribove (Methionyl bovine somatotropin). J Anim Sci 1994, 72, 2544-2551.
  30. Moriyama S, Yamamoto H, Sugimoto S, Abe T, Hirano T, Kawauchi H. Oral administration of recombinant salmon growth hormone to rainbow trout, Oncorhynchus mykiss. Aquaculture 1993, 112, 99-106. https://doi.org/10.1016/0044-8486(93)90161-Q
  31. Moseley WM, Paulissen JB, Goodwin MC, Alaniz GR, Claflin WH. Recombinant bovine somatotropin improves growth performance in finishing beef steers. J Anim Sci 1992, 70, 412-425.
  32. Radcliff RP, VandeHaar MJ, Skidmore AL, Chapin LT, Radke BR, Lloyd JW, Stanisiewski EP, Tucker HA. Effects of diet and bovine somatotropin on heifer growth and mammary development. J Dairy Sci 1997, 80, 1996-2003. https://doi.org/10.3168/jds.S0022-0302(97)76143-5
  33. Rose MT, Weekes TE, Rowlinson P. Correlation of blood and milk components with the milk yield response to bovine somatotropin in dairy cows. Domestic Anim Endocrinol 2005, 28, 296-307. https://doi.org/10.1016/j.domaniend.2004.12.001
  34. West JW, Mullinix BG, Sandifer TG. Effects of bovine somatotropin on physiologic responses of lactating Holstein and Jersey cows during hot, humid weather. J Dairy Sci 1991, 74, 840-851. https://doi.org/10.3168/jds.S0022-0302(91)78233-7
  35. White BR, Lan YH, McKeith FK, McLaren DG, Novakofski J, Wheeler MB, Kasser TR. Effects of porcine somatotropin on growth and carcass composition of Meishan and Yorkshire barrows. J Anim Sci 1993, 71, 3226-3238.