Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지
DOI QR코드

DOI QR Code

The Effects of 12-Weeks Intensive Intervention Program on Cardiovascular Risk Factors, Adipocytokines and Nutrients Intakes in Industrial Male Workers

12주 중재프로그램이 직장인의 심혈관질환 위험요인, 아디포사이토카인과 영양소 섭취에 미치는 영향

  • Moon, Ki-Eun (Radiation Health Research Institute, Korea& Hydro Nuclear Power Co., Ltd.) ;
  • Park, Ill-Keun (Radiation Health Research Institute, Korea& Hydro Nuclear Power Co., Ltd.) ;
  • Jo, Yeon-Sang (Radiation Health Research Institute, Korea& Hydro Nuclear Power Co., Ltd.) ;
  • Chang, Yun-Kyun (Radiation Health Research Institute, Korea& Hydro Nuclear Power Co., Ltd.) ;
  • Paek, Yun-Mi (Radiation Health Research Institute, Korea& Hydro Nuclear Power Co., Ltd.) ;
  • Choi, Tae-In (Radiation Health Research Institute, Korea& Hydro Nuclear Power Co., Ltd.)
  • 문기은 (한국수력원자력(주) 방사선보건연구원) ;
  • 박일근 (한국수력원자력(주) 방사선보건연구원) ;
  • 조연상 (한국수력원자력(주) 방사선보건연구원) ;
  • 장윤균 (한국수력원자력(주) 방사선보건연구원) ;
  • 백윤미 (한국수력원자력(주) 방사선보건연구원) ;
  • 최태인 (한국수력원자력(주) 방사선보건연구원)
  • Received : 2011.07.25
  • Accepted : 2011.08.19
  • Published : 2011.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Adipocytokines (adiponectin, leptin and resistin) are known to play a major role in development of cardiovascular disease (CVD) and intervention program is effective in reducing CVD risk factors. However, intervention program to improve the CVD risk factors including adipocytokines has been less studied. This study investigated the effects of 12-weeks worksite intervention program on cardiovascular risk factors, adipocytokines and nutrients intakes in industrial workers. 157 industrial male workers (32 metabolic syndrome (MS) subjects, 125 healthy subjects using age-matched stratified random sampling) received 5 face-to-face counseling based on their health profiles. Anthropometry, biochemical parameters and nutrients intakes were measured. The diagnosis of MS was adapted from modified NCEP-ATP III criteria (2001) and Asia-Pacific definition criteria (2000) for waist circumference (WC). After the intervention program, WC, BMI, SBP, insulin, leptin and intakes of total energy and fiber were significantly decreased (p < 0.05), while adiponectin was significantly increased (p < 0.05) in MS subjects. The WC, BMI, SBP, total cholesterol, LDL and HDL-cholesterol, HbA1c, leptin and intakes of total energy, protein and fat were significantly decreased (p < 0.05) and adiponectin was significantly increased (p < 0.05) in normal subjects. Multiple linear regression revealed that adiponectin was positively correlated with HDL-cholesterol (p < 0.01). Leptin was positively correlated with WC (p < 0.01), and resistin was positively correlated with HbA1c (p < 0.05) and intakes of total energy (p < 0.05), and negatively correlated with HDL-cholesterol (p < 0.05). The results of the 12 weeks intervention showed a positive impact on adipocytokines and nutrients intakes of industrial workers to reduce cardiovascular risk factors. Further research is needed to verify a tailored long-term worksite intervention program including adipocytokines as a protective factor for the CVD.

본 연구는 직장인 남성 근로자를 대상으로 12주 심혈관질환예방 중재프로그램이 신체계측, 혈중지질 및 아디포사이토카인, 영양소 섭취상태에 어떠한 영향을 미치는지 파악하고자 성인 남성 157명을 대상으로 실시되었다. 중재프로그램 전과 후를 비교 분석한 결과, 체중감량, 혈중지질 농도 및 인슐린 저항성 개선과 아디포사이토카인의 농도가 개선 되는 등 심혈관질환 위험 인자에 바람직한 영향을 미치는 것으로 나타났다. 아디포넥틴은 HDL-콜레스테롤, HOMA-IR과 연관성을 보였고, 렙틴은 허리둘레, 레지스틴은 HDL-콜레스테롤, HbA1c, 열량섭취와 연관성이 있는 것을 확인하였다. 이상의 연구에서처럼 12주 심혈관질환 예방 중재프로그램 수행 후에, 신체계측, 혈중 지질 농도 및 아디포사이토카인 농도가 효과적으로 개선됨을 알 수 있었고, 심혈관질환 위험 인자와 아디포사이토카인과의 연관성을 파악할 수 있었다. 향후에는 직장인 남성 근로자를 대상으로 심혈관질환 예방을 위한 전향적 연구가 이루어져야 할 것이다.

Keywords

References

  1. Statistics Korea. The cause of death statistics in 2009. 2010
  2. Meigs JB. Epidemiology of the metabolic syndrome, 2002. Am J Manag Care 2002; 8(11 Suppl): S283-292; quiz S293-296
  3. Oh HS, Jang M, Hwang MO, Cho SW, Paek YM, Choi TI, Park YK. Effect of 1 year e-mail nutrition education after face-toface encounter at worksite: changes in cardiovascular risk factors. Korean J Nutr 2009; 42(6): 559-566 https://doi.org/10.4163/kjn.2009.42.6.559
  4. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89(6): 2548-2556 https://doi.org/10.1210/jc.2004-0395
  5. Gannage-Yared MH, Khalife S, Semaan M, Fares F, Jambart S, Halaby G. Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men. Eur J Endocrinol 2006; 155(1): 167-176 https://doi.org/10.1530/eje.1.02175
  6. Park JY, Kim JW, Kim JM, Han Y, Park SK, Mok JY, Park MK, Lee HJ, Kim DK. Adiponectin concentrations in type 2 diabetic patients with or without metabolic syndrome. Korean Diabetes J 2008; 32(3): 224-235 https://doi.org/10.4093/kdj.2008.32.3.224
  7. Zhang SX, Guo HW, Wan WT, Xue K. Nutrition education guided by dietary guidelines for Chinese residents on metabolic syndrome characteristics, adipokines and inflammatory markers. Asia Pac J Clin Nutr 2011; 20(1): 77-86
  8. Heo KH, Won YL, Ko KS, Kim KW. Effects of obesity on the physiological levels of adiponectin, leptin and diagnostic indices of metabolic syndrome in male workers. Korean J Occup Health Nurs 2009; 18(1): 44-54
  9. Kajikawa Y, Ikeda M, Takemoto S, Tomoda J, Ohmaru N, Kusachi S. Association of circulating levels of leptin and adiponectin with metabolic syndrome and coronary heart disease in patients with various coronary risk factors. Int Heart J 2011; 52 (1): 17-22 https://doi.org/10.1536/ihj.52.17
  10. Osawa H, Ochi M, Tabara Y, Kato K, Yamauchi J, Takata Y, Nishida W, Onuma H, Shimizu I, Fujii Y, Miki T, Ohashi J, Makino H. Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes. Clin Endocrinol (Oxf) 2008; 69(1): 74-80 https://doi.org/10.1111/j.1365-2265.2007.03154.x
  11. Ryu ST, Park SO, Kim SH. The relation of serum adiponectin and resistin concentrations with metabolic risk factors. J Korean Soc Endocrinol 2005; 20(5): 444-451 https://doi.org/10.3803/jkes.2005.20.5.444
  12. Kwak W, Won JU, Rhie J, Lee MS, Kang EJ, Roh J. A workplace cardiovascular health promotion program and its short-term health effects. Korean J Occup Environ Med 2009; 21(1): 46-52
  13. Kang JY, Cho SW, Lee JY, Sung SH, Park YK, Paek YM, Choi TI. The effects of a worksite on-line health education program on metabolic syndrome risk factors and nutrient intakes of male workers. Korean J Nutr 2010; 43(1): 57-68 https://doi.org/10.4163/kjn.2010.43.1.57
  14. Racette SB, Deusinger SS, Inman CL, Burlis TL, Highstein GR, Buskirk TD, Steger-May K, Peterson LR. Worksite Opportunities for Wellness (WOW): effects on cardiovascular disease risk factors after 1 year. Prev Med 2009; 49(2-3): 108-114 https://doi.org/10.1016/j.ypmed.2009.06.022
  15. Groeneveld IF, Proper KI, van der Beek AJ, van Mechelen W. Sustained body weight reduction by an individual-based lifestyle intervention for workers in the construction industry at risk for cardiovascular disease: results of a randomized controlled trial. Prev Med 2010; 51(3-4): 240-246 https://doi.org/10.1016/j.ypmed.2010.07.021
  16. Baratta R, Amato S, Degano C, Farina MG, Patanè G, Vigneri R, Frittitta L. Adiponectin relationship with lipid metabolism is independent of body fat mass: evidence from both cross-sectional and intervention studies. J Clin Endocrinol Metab 2004; 89(6): 2665-2671 https://doi.org/10.1210/jc.2003-031777
  17. Corpeleijn E, Feskens EJ, Jansen EH, Mensink M, Saris WH, Blaak EE. Lifestyle intervention and adipokine levels in subjects at high risk for type 2 diabetes: the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM). Diabetes Care 2007; 30(12): 3125-3127 https://doi.org/10.2337/dc07-0457
  18. Lee SY, Lee KS, Koo JW, Yim HW, Kim HR, Park CY, Choi SK. Effectiveness of tailored health promotion program for reducing cardiovascular risk factors in subway workers. Korean J Occup Environ Med 2006; 18(1): 15-24
  19. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346(6): 393-403 https://doi.org/10.1056/NEJMoa012512
  20. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/ National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112(17): 2735-2752 https://doi.org/10.1161/CIRCULATIONAHA.105.169404
  21. WHO Western Pacific Region; International Association for the Study of Obesity; International Obesity Task Force. The Asia-Pacific perspective: redefining obesity and its treatment. Sydney, Australia: Health Communications; 2000
  22. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28(7): 412-419 https://doi.org/10.1007/BF00280883
  23. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285(19): 2486-2497 https://doi.org/10.1001/jama.285.19.2486
  24. Lee EH, Kim HK, Lee YH, Moon SY, Kwon EJ, Lee SH. Effectiveness of lifestyle intervention on the management of metabolic syndrome. J Korean Soc Health Educ Promot 2007; 24(3): 1-19
  25. Rosal MC, Ockene JK, Luckmann R, Zapka J, Goins KV, Saperia G, Mason T, Donnelly G. Coronary heart disease multiple risk factor reduction. Providers' perspectives. Am J Prev Med 2004; 27(2 Suppl): 54-60 https://doi.org/10.1016/j.amepre.2004.04.020
  26. Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, Nagai M, Matsuzawa Y, Funahashi T. Adiponectin as a biomarker of the metabolic syndrome. Circ J 2004; 68(11): 975-981 https://doi.org/10.1253/circj.68.975
  27. Yatagai T, Nagasaka S, Taniguchi A, Fukushima M, Nakamura T, Kuroe A, Nakai Y, Ishibashi S. Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. Metabolism 2003; 52(10): 1274-1278 https://doi.org/10.1016/S0026-0495(03)00195-1
  28. Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, Matsuzawa Y. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50(9): 2094-2099 https://doi.org/10.2337/diabetes.50.9.2094
  29. Utzschneider KM, Carr DB, Tong J, Wallace TM, Hull RL, Zraika S, Xiao Q, Mistry JS, Retzlaff BM, Knopp RH, Kahn SE. Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia 2005; 48(11): 2330-2333 https://doi.org/10.1007/s00125-005-1932-y
  30. Malo E, Ukkola O, Jokela M, Moilanen L, Kahonen M, Nieminen MS, Salomaa V, Jula A, Kesaniemi YA. Resistin is an indicator of the metabolic syndrome according to five different definitions in the Finnish health 2000 survey. Metab Syndr Relat Disord 2011; 9(3): 203-210 https://doi.org/10.1089/met.2010.0106
  31. Muto T, Yamauchi K. Evaluation of a multicomponent workplace health promotion program conducted in Japan for improving employees' cardiovascular disease risk factors. Prev Med 2001; 33(6): 571-577 https://doi.org/10.1006/pmed.2001.0923
  32. Yeon JY, Kim MH. A study on blood lipid levels, nutrient intakes, and oxidation and inflammation markers of overweight and obese adults according to blood cholesterol levels in Korea. Korean J Food Nutr 2011; 24(1): 1-11 https://doi.org/10.9799/ksfan.2011.24.1.001
  33. Luc G, Empana JP, Morange P, Juhan-Vague I, Arveiler D, Ferrieres J, Amouyel P, Evans A, Kee F, Bingham A, Machez E, Ducimetiere P. Adipocytokines and the risk of coronary heart disease in healthy middle aged men: the PRIME Study. Int J Obes (Lond) 2010; 34(1): 118-126 https://doi.org/10.1038/ijo.2009.204
  34. Park KS. Relation between adiponectin and metabolic risk factors. J Korean Soc Endocrinol 2005; 20(5): 441-443 https://doi.org/10.3803/jkes.2005.20.5.441
  35. Rokling-Andersen MH, Reseland JE, Veierod MB, Anderssen SA, Jacobs DR Jr, Urdal P, Jansson JO, Drevon CA. Effects of long-term exercise and diet intervention on plasma adipokine concentrations. Am J Clin Nutr 2007; 86(5): 1293-1301 https://doi.org/10.1093/ajcn/86.5.1293
  36. Kadoglou NP, Perrea D, Iliadis F, Angelopoulou N, Liapis C, Alevizos M. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes Care 2007; 30(3): 719-721 https://doi.org/10.2337/dc06-1149
  37. Riccardi G, Giacco R, Rivellese AA. Dietary fat, insulin sensitivity and the metabolic syndrome. Clin Nutr 2004; 23(4): 447-456 https://doi.org/10.1016/j.clnu.2004.02.006
  38. Park H, Kim E, Hwang M, Paek YM, Choi TI, Park YK. Effects of workplace nutrition education program tailored for the individual chronic disease risks. Korean J Nutr 2010; 43(3): 246-259 https://doi.org/10.4163/kjn.2010.43.3.246
  39. Kim M, Kim J, Bae W, Kim S, Lee Y, Na W, Sohn C. Relationship between Nutrients intakes, dietary quality, and serum concentrations of inflammatory markers in metabolic syndrome patients. Korean J Community Nutr 2011; 16(1): 51-61 https://doi.org/10.5720/kjcn.2011.16.1.51
  40. Jang M, Kim HR, Hwang MO, Paek YM, Choi TI, Park YK. The effect of repeated nutrition education on health improvement program by diet quality index-international (DQI-I) evaluation in office workers. Korean J Community Nutr 2010; 15(5): 614-624
  41. Sohn TS, Lee JM, Chang SA, Son HS, Ku YM, Cha BY, Lee KW, Son HY, Kang SK. The relation of serum adipokines with metabolic risk factors in type 2 diabetic subjects. J Korean Diabetes Assoc 2004; 28(6): 521-529
  42. Yannakoulia M, Yiannakouris N, Bluher S, Matalas AL, Klimis-Zacas D, Mantzoros CS. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. J Clin Endocrinol Metab 2003; 88(4): 1730-1736 https://doi.org/10.1210/jc.2002-021604

Cited by

  1. Development and Assessment of a Social Network Service-Based Lifestyle-Modification Program for Workers at High Risk of Developing Cardiovascular Disease vol.68, pp.3, 2011, https://doi.org/10.1177/2165079919864976