Development of Dual FDG Auto Synthesis Module

듀얼 FDG 자동합성장치 개발

  • Jeong, Cheol-Ki (Radiation Technology Enhancement Center, Chosun University) ;
  • Lee, Goung-Jin (Radiation Technology Enhancement Center, Chosun University) ;
  • Hur, Min-Goo (Advanced Radiation Technology Institute, KAERI) ;
  • Jang, Hong-Suk (Korea Institute of Radiological and Medical Sciences) ;
  • Min, Young-Don (Radiation Technology Enhancement Center, Chosun University)
  • Received : 2011.10.28
  • Accepted : 2011.11.30
  • Published : 2011.12.30

Abstract

[$^{18}F$]FDG (2-[$^{18}F$] Fluoro-2-deoxy-D-Glucose), which is required Automated Synthetic Module for production, is most often used Radiopharmaceuticals in nuclear medicine. In this study, an Automated Synthesis Module was developed to produce FDG in two consecutive time when F-18 feds continuously by modifying a domestic FDG Automated Synthetic Module on structural geometry and control system. The results were showed that the Average Synthesis Yields on the developed Automated Synthetic Module were $45{\pm}3%$ (n=20), $50{\pm}3%$ (n=20) respectively. The Quality Control results, such as Radio TLC, Radiochemical purity, Gamma-counter, pH, LAL Test, Micro bacteria test, showed in same level with domestic [$^{18}F$]FDG Auto-Synthetic modules. Therefore, if some features were improved by considering the components life time and appearance, commercial sales can be expected because of low price and easy maintenance compared with foreign products.

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Acknowledgement

Supported by : 한국연구재단