Journal of Ginseng Research

  • 제35권3호
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  • Pages.375-383
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  • 2011
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans

  • Lee, Joon-Hee (Department of Physical Therapy, Daebul University) ;
  • Ahn, Ji-Yun (Food Function Research Division, Korea Food Research Center) ;
  • Shin, Tae-Joon (Ginsentology Research Laboratory and Department of Physiology, Konkuk University College of Veterinary Medicine) ;
  • Choi, Sun-Hye (Ginsentology Research Laboratory and Department of Physiology, Konkuk University College of Veterinary Medicine) ;
  • Lee, Byung-Hwan (Ginsentology Research Laboratory and Department of Physiology, Konkuk University College of Veterinary Medicine) ;
  • Hwang, Sung-Hee (Ginsentology Research Laboratory and Department of Physiology, Konkuk University College of Veterinary Medicine) ;
  • Kang, Ji-Yeon (Ginsentology Research Laboratory and Department of Physiology, Konkuk University College of Veterinary Medicine) ;
  • Kim, Hyeon-Joong (Ginsentology Research Laboratory and Department of Physiology, Konkuk University College of Veterinary Medicine) ;
  • Park, Chan-Woo (Ginsentology Research Laboratory and Department of Physiology, Konkuk University College of Veterinary Medicine) ;
  • Nah, Seung-Yeol (Ginsentology Research Laboratory and Department of Physiology, Konkuk University College of Veterinary Medicine)
  • 투고 : 2011.06.08
  • 심사 : 2011.09.15
  • 발행 : 2011.09.25
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초록

In the previous report, we have demonstrated that ginsenoside Rc, one of major ginsenosides, is a major component for the restoration for normal growth of worms in cholesterol-deprived medium. In the present study, we further investigated the roles of minor ginsenosides, such as ginsenoside $Rh_1$ and $Rh_2$, ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) and ginsenoside epimers such as 20(R)- and 20(S)-ginsenoside $Rg_3$ in cholesterol-deprived medium. We found that ginsenoside $Rh_1$ almost restored normal growth of worms in cholesterol-deprived medium in F1 generation. However, supplement of ginsenoside $Rh_2$ caused a suppression of worm growths in cholesterol-deprived medium. In addition, CK and PPD also slightly restored normal growth of worms in cholesterol-deprived medium but PPT not. In experiments using ginsenoside epimers, supplement of 20(S)- but not 20(R)-ginsenoside $Rg_3$ in cholesterol-deprived medium also almost restored worm growth. These results indicate that the absence or presence of carbohydrate component at backbone of ginsenoside, the number of carbohydrate attached at carbon-3, and the position of hydroxyl group at carbon-20 of ginsenoside might plays important roles in restoration of worm growth in cholesterol-deprived medium.

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  2. Sphingomonas ginsenosidivorax sp. nov., with the ability to transform ginsenosides vol.103, pp.6, 2013, https://doi.org/10.1007/s10482-013-9916-2
  3. Characterization of a Ginsenoside-Transforming β-glucosidase from Paenibacillus mucilaginosus and Its Application for Enhanced Production of Minor Ginsenoside F2 vol.9, pp.1, 2014, https://doi.org/10.1371/journal.pone.0085727
  4. Identification and Characterization of a Ginsenoside-Transforming β-Glucosidase from Pseudonocardia sp. Gsoil 1536 and Its Application for Enhanced Production of Minor Ginsenoside Rg2(S) vol.9, pp.6, 2014, https://doi.org/10.1371/journal.pone.0096914
  5. Stereoisomer-Specific Anticancer Activities of Ginsenoside Rg3 and Rh2 in HepG2 Cells: Disparity in Cytotoxicity and Autophagy-Inducing Effects Due to 20(S)-Epimers vol.38, pp.1, 2015, https://doi.org/10.1248/bpb.b14-00603
  6. 20(S)-Protopanaxadiol Phospholipid Complex: Process Optimization, Characterization, In Vitro Dissolution and Molecular Docking Studies vol.21, pp.10, 2016, https://doi.org/10.3390/molecules21101396
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  8. Implication of the Stereoisomers of Ginsenoside Derivatives in the Antiproliferative Effect of HSC-T6 Cells vol.60, pp.47, 2011, https://doi.org/10.1021/jf303714c
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